Authors: Matthias May Atiqullah Aziz Sabine BrookmanMay Florian Roghmann Joachim Noldus Michael Rink Felix Chun Margit Fisch Vladimir Novotny Manfred Wirth Roman Mayr Armin Pycha Antonin Brisuda Björn Volkmer Regina Stredele Christopher Dechet Stefan Vallo Axel Haferkamp Marco Schnabel Stefan Denzinger Jan Roigas Christian G Stief Christian Gilfrich Patrick J Bastian Jörg B Engel Maximilian Burger HansMartin Fritsche
Publish Date: 2014/05/10
Volume: 33, Issue: 3, Pages: 343-350
Abstract
Our series comprised of 92 female patients in total of whom 87 with known invasion patterns were eligible for final analysis Median followup for evaluation of cancerspecific mortality CSM was 38 months interquartile ranges 21–82 months The impact on CSM was evaluated using multivariable Cox proportionalhazards regression analysis predictive accuracy PA was assessed by receiver operating characteristic analysisVaginal invasion was noted in 33 patients 379 group VAG uterine invasion in 20 patients 23 group UT and infiltration of both vagina and uterus in 34 patients 391 group VAG + UT Groups VAG and UT significantly differed from group VAG + UT with regard to the presence of positive soft tissue margins STM only Fiveyearcancerspecific survival probabilities in the groups VAG UT and VAG + UT were 21 20 and 21 respectively p = 0955 On multivariable analysis only STM status HR = 202 p = 0023 independently influenced CSM Cindices of multivariable models for CSM with and without integration of invasive patterns were 0570 and 0567 respectively PA gain 03 p = 0526Infiltration of the vagina the uterus or both is associated with poor 5year survival rates With regard to CSM no difference was detectable between patients with different invasion patterns thus justifying further collectively including these invasive patterns as stage pT4aThis study has been approved by the appropriate ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments All persons gave their informed consent prior to their inclusion in the study
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