Authors: Andrea Salonia Firas Abdollah Umberto Capitanio Andrea Gallina Nazareno Suardi Alberto Briganti Giuseppe Zanni Matteo Ferrari Fabio Castiglione Maria Chiara Clementi Patrizio Rigatti Francesco Montorsi
Publish Date: 2012/03/24
Volume: 31, Issue: 2, Pages: 275-280
Abstract
Sex steroids were assessed the day before surgery 7–11 am in a cohort of 605 patients with a median followup of 24 months following RP Cox regression models tested the association between predictors including age body mass index BMI prostatespecific antigen PSA clinical stage biopsy Gleason scores tT hypogonadism E2 and SHBG and early BCR defined as a PSA ≥ 01 ng/ml that occurred within 24 months after RPEarly BCR was found in 34 56 patients Patients with BCR did not differ in terms of age BMI serum PSA tT E2 and SHBG levels rate of hypogonadism and clinical stage as compared with those without BCR all p ≥ 005 Conversely patients with BCR showed a greater prevalence of biopsy Gleason scores ≥4 + 3 all p ≤ 0001 At multivariable Cox regression analysis tT hazard ratio HR 143 p = 003 E2 HR 105 p = 004 SHBG HR 129 p = 002 and biopsy Gleason scores equal to 4 + 3 HR 337 p = 004 and ≥8 HR 2006 p 0001 achieved independent predictor status for early BCR Conversely no significant associations were found for all the other predictors
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