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Title of Journal: World J Urol

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Abbravation: World Journal of Urology

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Springer Berlin Heidelberg

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DOI

10.1006/jcat.1995.1073

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1433-8726

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The impact of smoking on pathologic response to ne

Authors: Philip H Kim Matthew Kent Philip Zhao John P Sfakianos Dean F Bajorin Bernard H Bochner Guido Dalbagni
Publish Date: 2013/07/11
Volume: 32, Issue: 2, Pages: 453-459
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Abstract

Smoking is the primary etiologic risk factor for bladder cancer and has been implicated in mechanisms of chemoresistance We investigated smoking as a potential predictor for pathologic outcomes after neoadjuvant chemotherapy NC and radical cystectomy RC for muscleinvasive bladder cancerWe identified 139 patients treated with neoadjuvant cisplatinbased chemotherapy followed by RC for T24aN0M0 bladder cancer Logistic regression was used to evaluate associations between smoking characteristics and pathologic outcomes pT0 complete response pT0/pTis/pT1 any response In a secondary analysis multivariate Cox regression was used to assess associations between smoking and recurrencefree and cancerspecific survivalOur cohort consisted of 99 71  males with a median age of 65 interquartile range 56 71 Prevalence of never former and current smokers was 25 45 and 29  respectively In total 63 patients experienced disease recurrence 39 died of disease and 11 died of other causes There were no statistically significant associations between smoking characteristics and complete p = 05 or any p = 02 pathologic response to NC Similarly we did not find any association between smoking characteristics and recurrence p = 06 or cancerspecific survival p = 09In this series smoking characteristics were not found to be predictive of pathologic response after NC and RC although this analysis was limited by the small study sample size However the harmful effects of smoking warrants continued emphasis on smoking cessation counseling in bladder cancer patients


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  6. Improved performance of SPECT-CT In-111 capromab pendetide by correlation with diffusion-weighted magnetic resonance imaging for identifying metastatic pelvic lymphadenopathy in prostate cancer
  7. Which factors affect the hospital re-admission and re-hospitalization after flexible ureterorenoscopy for kidney stone?
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  10. Is multichannel urodynamic assessment necessary before considering a surgical treatment of BPH? Pros and cons
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  12. Influence of age on false positive rates of urine-based tumor markers
  13. Phosphodiesterase type 2 distribution in the guinea pig urinary bladder
  14. Changing concepts in the surgery of renal cell carcinoma
  15. Association of polymorphisms in CYP19A1 and CYP3A4 genes with lower urinary tract symptoms, prostate volume, uroflow and PSA in a population-based sample
  16. Reduction in incidence of lymphocele following extraperitoneal radical prostatectomy and pelvic lymph node dissection by bilateral peritoneal fenestration
  17. Should inclusion criteria for active surveillance for low-risk prostate cancer be more stringent? From an interim analysis of PRIAS-JAPAN
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  28. 3D Navigo™ versus TRUS-guided prostate biopsy in prostate cancer detection
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  43. Preoperative sex steroids are significant predictors of early biochemical recurrence after radical prostatectomy
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