Authors: Philip H Kim Matthew Kent Philip Zhao John P Sfakianos Dean F Bajorin Bernard H Bochner Guido Dalbagni
Publish Date: 2013/07/11
Volume: 32, Issue: 2, Pages: 453-459
Abstract
Smoking is the primary etiologic risk factor for bladder cancer and has been implicated in mechanisms of chemoresistance We investigated smoking as a potential predictor for pathologic outcomes after neoadjuvant chemotherapy NC and radical cystectomy RC for muscleinvasive bladder cancerWe identified 139 patients treated with neoadjuvant cisplatinbased chemotherapy followed by RC for T24aN0M0 bladder cancer Logistic regression was used to evaluate associations between smoking characteristics and pathologic outcomes pT0 complete response pT0/pTis/pT1 any response In a secondary analysis multivariate Cox regression was used to assess associations between smoking and recurrencefree and cancerspecific survivalOur cohort consisted of 99 71 males with a median age of 65 interquartile range 56 71 Prevalence of never former and current smokers was 25 45 and 29 respectively In total 63 patients experienced disease recurrence 39 died of disease and 11 died of other causes There were no statistically significant associations between smoking characteristics and complete p = 05 or any p = 02 pathologic response to NC Similarly we did not find any association between smoking characteristics and recurrence p = 06 or cancerspecific survival p = 09In this series smoking characteristics were not found to be predictive of pathologic response after NC and RC although this analysis was limited by the small study sample size However the harmful effects of smoking warrants continued emphasis on smoking cessation counseling in bladder cancer patients
Keywords: