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Title of Journal: J Clin Immunol

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Abbravation: Journal of Clinical Immunology

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Springer-Verlag

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10.1016/0300-9432(75)90085-0

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1573-2592

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RETRACTED ARTICLE OleandrinMediated Expression o

Authors: YASHIN SREENIVASAN PONGALI B RAGHAVENDRA SUNIL K MANNA
Publish Date: 2006/06/16
Volume: 26, Issue: 4, Pages: 308-322
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Abstract

Chemotherapeutic agent is characterized by its concentration in tumor cells with minimum side effects Oleandrin a polyphenolic cardiac glycoside is known to induce apoptosis in tumor cells However no report is available on its efficacy in primary cells In this report we are providing the evidence that oleandrin induces apoptosis not necrosis in tumor cells but not in primary cells like peripheral blood mononuclear cells PBMC and neutrophils Oleandrin inhibited NFκB activation in tumor cells but not in primary cells It induced cell death in NFκBoverexpressed tumor cells Oleandrin induced Fas expression thereby inducing apoptosis in tumor cells but not in primary cells Dominant negative FADD inhibited oleandrininduced cell death in tumor cells Overall these results suggest that oleandrin mediates apoptosis in tumor cells by inducing Fas but not in primary cells indicating its potential anticancer property with no or slight side effect

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