Journal Title
Title of Journal: J Clin Immunol
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Abbravation: Journal of Clinical Immunology
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Authors: Elena Matteucci Massimo Ghimenti Serena Di Beo Ottavio Giampietro
Publish Date: 2011/09/02
Volume: 31, Issue: 6, Pages: 977-984
Abstract
Type 1 diabetes is an autoimmune process predominantly Tcell mediated CD26 plays a role in Tcell costimulation migration memory development thymic maturation and emigration patterns In peripheral blood from 55 patients with type 1 diabetes and 20 healthy controls CD4+ and CD8+ T cells expressing CD26 were differentiated into naïve N CD45RA+CCR7+ central memory CM CD45RA−CCR7+ effector memory EM CD45RA−CCR7− and terminally differentiated effector memory TEMRA CD45RA+CCR7− In type 1 diabetes CD4+ and CD8+ T cells expressing CD26 showed a distinctive differentiation profile percentages and absolute numbers of CM and N cells were reduced whereas those of TEMRA cells were markedly increased The indices of intermediate and longterm glycaemic control were associated negatively with the number of CM and N cells while positively with the number of TEMRA cells The considerable accumulation of TEMRA T cells in our patients suggests lifelong stimulation by protracted antigen exposure viruses other agents or residual selfantigens or a homeostatic defect in the regulation/contraction of immune responses
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- Associations Between Autoimmune Thyroid Disease Prognosis and Functional Polymorphisms of Susceptibility Genes, CTLA4 , PTPN22 , CD40 , FCRL3 , and ZFAT , Previously Revealed in Genome-wide Association Studies
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