Journal Title
Title of Journal: J Clin Immunol
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Abbravation: Journal of Clinical Immunology
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Authors: Ilan Bank Shomron BenHorin Itamar Goldstein Alexander Koltakov Pnina Langevitz Michael Ehrenfeld Esther Rosenthal Hanan Gur
Publish Date: 2007/09/22
Volume: 27, Issue: 6, Pages: 580-588
Abstract
The α1β1 integrin very late antigen VLA1 characterizes collagen adherent interferon IFN γ producing memory T cells in inflamed synovium We now report that the mean percentage of VLA1+ T cells is significantly lower among peripheral blood mononuclear cells of rheumatoid patients responsive to antitumor necrosis factor TNF α therapy than of those with active disease not receiving therapy Neutralization of TNFα during in vitro polyclonal activation of VLA1− T cells reduced differentiation to expression of VLA1 and inhibited secretion of IFNγ but did not affect integrin expression on in vivo differentiated VLA1+ T cells Moreover synovial fluids of patients relapsing during and after therapy were enriched in VLA1+ T cells and lines derived from VLA1+ T cells in peripheral blood of treated patients retained collagen binding and secreted IFN γ Thus whereas therapy decreases VLA1+ T cells in rheumatoid arthritis patients a subset is resistant and contributes to residual and recurring inflammation
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