Journal Title
Title of Journal: J Clin Immunol
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Abbravation: Journal of Clinical Immunology
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Authors: János P Kósa Bernadett Balla János Kiss János Podani István Takács Áron Lazáry Zsolt Nagy Krisztián Bácsi Attila Karsai Gábor Speer Péter Lakatos
Publish Date: 2009/08/07
Volume: 29, Issue: 6, Pages: 761-
Abstract
The molecular and cellular interactions between the immune system and bone tissue have been established Sex hormone deficiency after menopause has multifunctional role by influencing growth differentiation and metabolism of the skeletal and the immune systemWe have used nonparametric and multidimensional expression pattern analyses to determine significantly changed mRNA profile of immune systemassociated genes in postmenopausal POST and premenopausal PRE nonosteoporotic bone Ten bone tissue samples from POST patients and six bone tissue samples from PRE women were examined in our study The transcription differences of the selected 50 genes were analyzed in TaqMan probebased quantitative realtime reverse transcriptase polymerase chain reaction system Mann–Whitney test indicated significantly downregulated transcription activity of three genes CD14 HLAA/MHCI ITGAM/CD11b and upregulated expression of six genes C3 CD86/B72 IL10 IL6 TGFB3 TNFSF11/RANKL in postmenopausal bone According to the canonical variate analysis results the groups of POST and PRE women are separable by genes coding for cytokines costimulator molecules and cell surface receptors involved in antigen presentation and T cell stimulation processes which have high discriminatory power Based on a complex gene expression pattern analysis of human bone tissue we could distinguish POST and PRE states from an immunological aspect Our data might provide further insight into the changes of the intersystem crosstalk between immune and skeletal homeostasis as well as local immune response in the altered microenvironment of postmenopausal boneThis work was supported by grants NKFP1A/007/2004 and NKFP1A/002/2004 from the National Research and Technological Office NKTH of Hungary as well as by research grant ETT 022/2006 from the Ministry of Health Hungary J Podani was supported by a Hungarian Scientific Research Fund OTKA grant no NI 68218 J Kiss was supported by OTKA grant no T037436
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