Journal Title
Title of Journal: J Clin Immunol
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Abbravation: Journal of Clinical Immunology
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Authors: HeeKap Kang MingYi Chiang Michael Liu Diane Ecklund Syamal K Datta
Publish Date: 2011/02/03
Volume: 31, Issue: 3, Pages: 379-394
Abstract
Tolerance therapy with nucleosomal histone peptides H471–94 H416–39 or H1′22–42 controls disease in lupusprone SNF1 mice It would be clinically important to determine whether a cocktail of the above epitopes would be superior Herein we found that compared with cocktail peptides H471–94 monotherapy more effectively delayed nephritis onset prolonged lifespan diminished immunoglobulin G autoantibody levels reduced autoantigenspecific Th1 and Th17 responses and frequency of TFH cells in spleen and the helper ability of autoimmune T cells to B cells by inducing potent CD8 Treg cells H471–94 therapy was superior in “tolerance spreading” suppressing responses to other autoepitopes nucleosomes and ribonucleoprotein We also developed an in vitro assay for therapeutic peptides potentially in humans which showed that H471–94 without exogenous transforming growth factor TGFβ was efficient in inducing stable CD4+CD25+Foxp3+ T cells by decreasing interleukin 6 and increasing TGFβ production by dendritic cells that induced ALK5dependent Smad3 phosphorylation TGFβ signal in target autoimmune CD4+ T cells
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- Increased T-Cell Activation and Th1 Cytokine Concentrations Prior to the Diagnosis of B-Cell Lymphoma in HIV Infected Patients
- Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes
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- First Report on the Moroccan Registry of Primary Immunodeficiencies: 15 Years of Experience (1998–2012)
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- Recent Advances in DOCK8 Immunodeficiency Syndrome
- Development of Primary Immunodeficiencies in Africa
- Streptococcal Infections in Patients with Chronic Granulomatous Disease: Case Report and Review of the Literature
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- The Effect of Blockade of Tumor Necrosis Factor α on VLA-1+T-Cells in Rheumatoid Arthritis Patients
- Associations Between Autoimmune Thyroid Disease Prognosis and Functional Polymorphisms of Susceptibility Genes, CTLA4 , PTPN22 , CD40 , FCRL3 , and ZFAT , Previously Revealed in Genome-wide Association Studies
- CTLA-4 Gene Exon-1 +49 A/G Polymorphism: Lack of Association with Autoimmune Disease in Patients with Common Variable Immune Deficiency
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