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Title of Journal: J Clin Immunol

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Abbravation: Journal of Clinical Immunology

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Springer US

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DOI

10.1007/s11232-005-0085-y

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ISSN

1573-2592

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BCell and TCell Phenotypes in CVID Patients Corr

Authors: Gaël Mouillot Maryvonnick Carmagnat Laurence Gérard JeanLuc Garnier Claire Fieschi Nicolas Vince Lionel Karlin JeanFrançois Viallard Roland Jaussaud Julien Boileau Jean Donadieu Martine Gardembas Nicolas Schleinitz Felipe Suarez Eric Hachulla Karen Delavigne Martine Morisset Serge Jacquot Nicolas Just Lionel Galicier Dominique Charron Patrice Debré Eric Oksenhendler Claire Rabian for the DEFI Study Group
Publish Date: 2010/05/01
Volume: 30, Issue: 5, Pages: 746-755
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Abstract

In patients developing infection only IO the main Bcell or Tcell abnormalities were a defect in switched memory B cells and a decrease in naive CD4+ T cells associated with an increase in CD4+CD95+ cells These abnormalities were more pronounced in patients developing lymphoproliferation LP autoimmune cytopenia AC or chronic enteropathy CE Moreover LP and AC patients presented an increase in CD21low B cells and CD4+HLADR+ T cells and a decrease in regulatory T cellsIn these large series of CVID patients the major abnormalities of the Bcell and Tcell compartments although a hallmark of CVID were only observed in half of the IO patients and were more frequent and severe in patients with additional lymphoproliferative autoimmune and digestive complicationsClinical Centers Hôpital Saint Louis Paris C Fieschi M Malphettes L Galicier S Georgin JP Fermand Bordeaux JF Viallard Limoges A Jaccard Tours C Hoarau Y Lebranchu Hôpital Cochin Paris A Bérezné L Mouthon HEGP Paris M Karmochkine Marseille N Schleinitz Lyon Sud I Durieu R NoveJosserand ClermontFerrand V Chanet Montpellier V LeMoing Roubaix N Just HôtelDieu Paris C Salanoubat Reims R Jaussaud Hôpital Necker Paris F Suarez O Hermine Le Mans P SolalCeligny Lille E Hachulla Perpignan L Sanhes Angers M Gardembas I Pellier Troyes P Tisserant Lyon Armée M Pavic Dijon B Bonnotte PitiéSalpêtrière Paris J Haroche Z Amoura Toulouse L Alric MF Thiercelin L Tetu D Adoue Nancy Vandoeuvre P Bordigoni Lyon Croix Rousse T Perpoint Lyon HotelDieu P Sève Besançon P Rohrlich Strasbourg JL Pasquali P Soulas Hôpital Foch Suresnes LJ Couderc Montauban P Giraud Hôpital SaintLouis Pédiatrie Paris A Baruchel ClermontFerrand 2 I Deleveau KremlinBicêtre F Chaix Hôpital Trousseau Paris J Donadieu Rouen F Tron Bobigny C Larroche Aix AP Blanc Nantes A Masseau M Hamidou Nancy G Kanny M Morisset Poitiers F Millot Bondy O Fain Hôpital Bichat Paris R Borie Rennes A Perlat


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  3. Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity
  4. Altered Proportions of Naïve, Central Memory and Terminally Differentiated Central Memory Subsets among CD4 + and CD8 + T Cells Expressing CD26 in Patients with Type 1 Diabetes
  5. A Complement Factor B Mutation in a Large Kindred with Atypical Hemolytic Uremic Syndrome
  6. Severe Combined Immunodeficiency (SCID) in Canadian Children: A National Surveillance Study
  7. Postmenopausal Expression Changes of Immune System-Related Genes in Human Bone Tissue
  8. RETRACTED ARTICLE: Oleandrin-Mediated Expression of Fas Potentiates Apoptosis in Tumor Cells
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  10. Simultaneous Positivity for Anti-DNA, Anti-Nucleosome and Anti-Histone Antibodies is a Marker for More Severe Lupus Nephritis
  11. Increased T-Cell Activation and Th1 Cytokine Concentrations Prior to the Diagnosis of B-Cell Lymphoma in HIV Infected Patients
  12. Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes
  13. First Report on the Moroccan Registry of Primary Immunodeficiencies: 15 Years of Experience (1998–2012)
  14. Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation
  15. The Histone Peptide H4 71–94 Alone Is More Effective than a Cocktail of Peptide Epitopes in Controlling Lupus: Immunoregulatory Mechanisms
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  17. Recent Advances in DOCK8 Immunodeficiency Syndrome
  18. Development of Primary Immunodeficiencies in Africa
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  22. Associations Between Autoimmune Thyroid Disease Prognosis and Functional Polymorphisms of Susceptibility Genes, CTLA4 , PTPN22 , CD40 , FCRL3 , and ZFAT , Previously Revealed in Genome-wide Association Studies
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