Journal Title
Title of Journal: J Clin Immunol
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Abbravation: Journal of Clinical Immunology
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Authors: David Eric Ouedraogo Alain Makinson Nils Kuster Nicolas Nagot PierreAlain Rubbo Karine Bollore Vincent Foulongne Guillaume Cartron Daniel Olive Jacques Reynes JeanPierre Vendrell Edouard Tuaillon
Publish Date: 2012/08/23
Volume: 33, Issue: 1, Pages: 22-29
Abstract
Despite the use of combined antiretroviral therapy HIVinfected individuals have a higher risk of developing Bcell lymphoma compared to the general population We aim to explore whether lymphocyte activation increase in Th1 response as well as markers of EBV reactivation may precede lymphoma diagnosisThirteen cases and 26 controls matched on CD4+ Tcell count and HIV plasma viral load were identified Samples were collected 0 to 5 years prior to Bcell lymphoma diagnosis Seven out of 13 54 and 16/26 615 of cases and controls were receiving antiretroviral therapy at the time of sampling respectively CD8+ Tcell activation and Th1 cytokine concentrations were measured before lymphoma onset together with IgG antibodies directed against viral capsid antigen VCA and serum levels of EBV DNAA higher level of CD8+ Tcell activation was observed in patients developing lymphoma Four out of seven Th1 cytokine serum concentrations were significantly higher in patients with lymphoma than in the control group IL2R IL12p40/70 IFNγinducible protein 10 IP10 and monokine induced by IFNγ MIG AntiVCA IgG level were significantly higher in cases than in controls Four cases 30 but no controls had detectable EBV DNA in serumA higher level of Tcell activation Th1 cytokine serum concentration and markers of EBV replication preceded Bcell lymphoma diagnosis This may suggest that viral antigen stimulation is associated with the genesis of lymphoma in HIVinfected patientsWe are grateful to Infectiopole Sud for their financial support We would also like to thank Emily Witty and Johannes Viljoen for the English review of the manuscript This work was presented at the 6ème conférence francophone VIH/SIDA AFRAVIH 2012 Geneva Switzerland 25th to 28th of March 2012
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