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Title of Journal: J Clin Immunol

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Abbravation: Journal of Clinical Immunology

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Springer US

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DOI

10.1016/0962-8479(94)90934-2

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1573-2592

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Recent Advances in DOCK8 Immunodeficiency Syndrome

Authors: Qian Zhang Huie Jing Helen C Su
Publish Date: 2016/05/20
Volume: 36, Issue: 5, Pages: 441-449
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Abstract

Since the discovery of the genetic basis of DOCK8 immunodeficiency syndrome DIDS in 2009 several hundred patients worldwide have been reported validating and extending the initial clinical descriptions Importantly the beneficial role of hematopoietic stem cell transplantation for this disease has emerged providing impetus for improved diagnosis Additionally several groups have further elucidated the biological functions of DOCK8 in the immune system that help explain disease pathogenesis Here we summarize these recent developmentsThis work was supported by the Intramural Research Program NIH National Institute of Allergy and Infectious Diseases Data in Fig 2 were generated after obtaining written informed consent from the patient on an NIAID IRBapproved research protocol

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