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Title of Journal: J Clin Immunol

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Abbravation: Journal of Clinical Immunology

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Springer US

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DOI

10.1007/bf01765485

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1573-2592

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Associations Between Autoimmune Thyroid Disease Pr

Authors: Naoya Inoue Mikio Watanabe Hiroya Yamada Kazuya Takemura Fumiaki Hayashi Noriko Yamakawa Maiko Akahane Yu Shimizuishi Yoh Hidaka Yoshinori Iwatani
Publish Date: 2012/06/17
Volume: 32, Issue: 6, Pages: 1243-1252
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Abstract

Genomewide association studies have revealed several susceptibility genes among patients with autoimmune thyroid disease AITD including CTLA4 PTPN22 FCRL3 and ZFAT However any possible association between these genes and AITD prognosis remains unknown The objective of this study was to identify associations between polymorphisms of these genes and AITD prognosisWe genotyped functional polymorphisms including CTLA4 CT60 CTLA4 +49A/G CTLA4 1147C/T CTLA4 318C/T PTPN22 1123C/G PTPN22 SNP37 CD40 1C/T FCRL3 169C/T ZFAT Ex9bSNP10 and ZFAT Ex9bSNP2 in 197 AITD patients carefully selected from 456 registered AITD patients and 86 control subjects The restriction fragment length polymorphism method was used for genotypingThe CD40 1CC genotype and C allele were significantly more frequent in patients with Graves’ disease GD in remission than in those with intractable GD P = 0041 and P = 0031 respectively The FCRL3 169TT genotype was significantly less frequent in patients with intractable GD than in those with GD in remission P = 00324 For a ZFAT Ex9bSNP10 polymorphism the TT genotype and T allele were significantly more frequent in patients with severe Hashimoto’s disease HD than in those with mild HD P = 00029 and P = 00049 respectively For a CTLA4 CT60 polymorphism the antithyrotropin receptor antibody levels at the onset of GD were significantly higher in those with the GG genotype than in those with other genotypes P = 00117

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