Influence of Maternal Hyperglycemia on IL10 and T

Authors: Jusciele Brogin Moreli Glilciane Morceli Ana Karina C De Luca Claudia G Magalhães Roberto A A Costa Débora Cristina Damasceno Marilza Vieira Cunha Rudge Iracema Mattos Paranhos Calderon

Publish Date: 2011/12/30

Volume: 32, Issue: 3, Pages: 604-610

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Abstract

This study was conducted to evaluate maternal and placental concentrations of interleukin 10 IL10 and tumor necrosis factoralpha TNFα in pregnant women with glycemic mean GM or ≥100 mg/dL as well as correlate IL10 and TNFα placental concentrations with perinatal outcomesOne hundred eightysix pregnant women were distributed in groups determined by a GM 100 mg/dL or a GM ≥100 mg/dL The GM HbA1c levels maternal and placental concentrations of IL10 and TNFα and the correlation of placental cytokines with perinatal outcomes were evaluatedIn maternal blood the lowest concentrations of IL10 p = 00019 and TNFα p = 00185 were observed in the GM ≥100mg/dL group The placentas from GM ≥100 mg/dL group exhibited higher TNFα concentrations p = 00385 Placental IL10 directly correlated with hemoglobin r = 063 p = 002 and insulin r = 078 p = 001 levels in the umbilical cord and with 1min r = 053 p = 00095 and 5min r = 069 p = 00003 Apgar scores Placental TNFα displayed a tendency to inversely correlate with fetal weight r = −041 p = 005Compared to GM 100 mg/dL GM ≥100 mg/dL was associated with a reduction in maternal IL10 and TNFα concentrations and increased placental TNFα production Placental IL10 production was similar in both groups studied and directly correlated with hemoglobin and umbilical cord insulin levels as well as with the 1 and 5min Apgar scoresThe authors thank the São Paulo Research Foundation Fundação de Amparo à Pesquisa do Estado de São Paulo—FAPESP grant number 2007/00716 and 2009/032531 for financial support and the Research Support Group Grupo de Apoio a Pesquisa—GAP of Botucatu Medical School/UNESP for their technical support in statistical analysis

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