Journal Title
Title of Journal: J Clin Immunol
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Abbravation: Journal of Clinical Immunology
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Authors: HaiDan Chen Xia Zhou Gang Yu YingLan Zhao Yushan Ren YiDan Zhou Qiao Li XiaoLian Zhang
Publish Date: 2012/03/06
Volume: 32, Issue: 4, Pages: 820-836
Abstract
Core 1 beta 13galactosyltransferase also known as Tantigensynthase or Tsynthase is a key enzyme for the synthesis of the common core 1 Oglycan structure Tantigen Although Tsynthase is known to be important in human immunerelated diseases the effects of Tsynthase and Tantigen on host immune responses remain poorly defined In this study a Tsynthasespecific short hairpin RNA shRNA was transfected into murine colon carcinoma CT26 cells or mouse muscle tissues via intramuscular electroporation to assess the effects of Tsynthase on T cells and cytokines Tsynthase knockdown significantly induced galectin1 secretion both in vivo and in vitro and strongly enhanced Th2 cytokine IL10 and IL4 production in vivo Further the increased production of galectin1 induced by Tsynthase knockdown promoted CD8+ Tcell apoptosis which when combined with the increased production of CD4+ T cellderived Th2 cytokines prolonged the survival of skin allografts in mice Our data suggest core 1 beta 13galactosyltransferaseshRNA could serve not only as a useful tool in organ transplantation but also as a powerful tool for investigating Oglycans and glycoprotein synthesis and function
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- A Complement Factor B Mutation in a Large Kindred with Atypical Hemolytic Uremic Syndrome
- Severe Combined Immunodeficiency (SCID) in Canadian Children: A National Surveillance Study
- Postmenopausal Expression Changes of Immune System-Related Genes in Human Bone Tissue
- RETRACTED ARTICLE: Oleandrin-Mediated Expression of Fas Potentiates Apoptosis in Tumor Cells
- BAK , BAX , and NBK / BIK Proapoptotic Gene Alterations in Iranian Patients with Ataxia Telangiectasia
- Simultaneous Positivity for Anti-DNA, Anti-Nucleosome and Anti-Histone Antibodies is a Marker for More Severe Lupus Nephritis
- Increased T-Cell Activation and Th1 Cytokine Concentrations Prior to the Diagnosis of B-Cell Lymphoma in HIV Infected Patients
- Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes
- B-Cell and T-Cell Phenotypes in CVID Patients Correlate with the Clinical Phenotype of the Disease
- First Report on the Moroccan Registry of Primary Immunodeficiencies: 15 Years of Experience (1998–2012)
- Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation
- The Histone Peptide H4 71–94 Alone Is More Effective than a Cocktail of Peptide Epitopes in Controlling Lupus: Immunoregulatory Mechanisms
- Histamine Release and Inflammatory Cell Infiltration in Airway Mucosa in Methylene Diphenyl Diisocyanate (MDI)-Induced Occupational Asthma
- Recent Advances in DOCK8 Immunodeficiency Syndrome
- Development of Primary Immunodeficiencies in Africa
- Streptococcal Infections in Patients with Chronic Granulomatous Disease: Case Report and Review of the Literature
- Presenting features and platelet anomalies in WAS: one centre’s experience
- The Effect of Blockade of Tumor Necrosis Factor α on VLA-1+T-Cells in Rheumatoid Arthritis Patients
- Associations Between Autoimmune Thyroid Disease Prognosis and Functional Polymorphisms of Susceptibility Genes, CTLA4 , PTPN22 , CD40 , FCRL3 , and ZFAT , Previously Revealed in Genome-wide Association Studies
- CTLA-4 Gene Exon-1 +49 A/G Polymorphism: Lack of Association with Autoimmune Disease in Patients with Common Variable Immune Deficiency
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