Authors: F Godinho S Thobois M Magnin M Guenot G Polo I Benatru J Xie A Salvetti L GarciaLarrea E Broussolle P Mertens
Publish Date: 2006/06/20
Volume: 253, Issue: 10, Pages: 1347-1355
Abstract
1 To assess the anatomical localization of the active contacts of deep brain stimulation targeted to the subthalamic nucleus STN in Parkinson’s disease patients 2 To analyze the stereotactic spatial distribution of the active contacts in relation to the dorsal and the ventral electrophysiologicallydefined borders of the STN and the stereotactic theoretical targetTwentyeight patients underwent bilateral highfrequency stimulation of the STN HFSSTN An indirect anatomical method based on ventriculography coupled to electrophysiological techniques were used to localize the STN Clinical improvement was evaluated by Unified Parkinson’s Disease Rating Scale motor score UPDRS III The normalized stereotactic coordinates of the active contact centres dorsal and ventral electrophysiologicallydefined borders of the STN were obtained from intraoperative Xrays images These coordinates were represented in a threedimensional stereotactic space and in the digitalized atlas of the human basal gangliaHFSSTN resulted in significant improvement of motor function 628 in offmedication state and levodopaequivalent dose reduction of 687 p 005 Most of the active contacts 786 were situated close to ± 16 mm the dorsal border of the STN STNDB while 16 were dorsal and 54 were ventral to it Similar distribution was observed in the atlas The euclidean distance between the STNDB distribution center and the active contacts distribution center was 031 mm while the distance between the active contacts distribution center and the stereotactic theoretical target was 215 mm Most of the space defined by the active contacts distribution 53 was inside that defined by the STNDB distribution
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