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Title of Journal: J Neurol

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Abbravation: Journal of Neurology

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D. Steinkopff-Verlag

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DOI

10.1007/bf02816982

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1432-1459

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Electrophysiological features of lateonset transt

Authors: H Koike Y Kawagashira M Iijima M Yamamoto N Hattori F Tanaka M Hirayama Y Ando Si Ikeda G Sobue
Publish Date: 2008/09/24
Volume: 255, Issue: 10, Pages: 1526-
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Abstract

The extent of the reduction of the compound muscle action potential and especially the sensory nerve action potential was more profound in the lateonset group even when the decline of these indices with aging in normal control subjects was taken into account The feature of predominant lowerlimb involvement seemed to be more conspicuous in the lateonset group Electrophysiological indices tended to be aggravated as the duration of neuropathic symptoms increased in the earlyonset group while most of these indices in the lateonset group did not show this correlation A slowing of conduction velocity and a prolongation of distal latency which suggests demyelination were conspicuous in some patients Pathologically a predominant loss of smallfibers was not conspicuous in sural nerve biopsy specimens from lateonset patients Large myelinated fiber density showed a negative correlation with the disease duration in earlyonset cases but not in lateonset cases

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