Authors: Georgios Koutsis Marios Panas Georgia Karadima Dimitris Mandellos Constantinos Sfagos Constantin Potagas Demetris Vassilopoulos
Publish Date: 2007/03/07
Volume: 254, Issue: 3, Pages: 394-395
Abstract
Sirs Evidence on the influence of apolipoprotein E APOE polymorphisms on multiple sclerosis MS disease severity has been controversial Several studies have associated the ε4 polymorphism with more rapid progression 1 2 7 Others have not confirmed this 5 6 10 11 The MS severity score MSSS was recently developed as a powerful method for comparing disease progression in genetic association studies 4 In the present study we investigated the effect of APOE genotypes on disease severity in Greek MS patients a previously unstudied population using the MSSSAPOE genotypes were determined in 212 Greek patients 135 females 77 males with MS McDonald criteria under the care of the Neurology Department University of Athens 3 Only patients with disease duration of at least one year were included Mean patient age was 387 ± 104 years range 16–69 mean age at onset 301 ± 99 years range 10–64 mean disease duration 86 ± 67 years range 1–39 mean EDSS
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