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Title of Journal: J Neurol

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Abbravation: Journal of Neurology

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D. Steinkopff-Verlag

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DOI

10.1007/bf02874496

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1432-1459

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The relationship between impairment of voluntary m

Authors: Jiří Klempíř Olga Klempířová Jan Štochl Nataša Špačková Jan Roth
Publish Date: 2009/05/16
Volume: 256, Issue: 10, Pages: 1629-1633
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Abstract

The relationship between motor symptoms and cognitive impairment in Huntington’s disease HD is still discussed We analysed 45 HD patients in various stages using Unified Huntington’s Disease Rating Scale motor subscale voluntary and involuntary components were evaluated separately verbal memory and executive functions tests Partial correlations controlling for HD duration and age were used to estimate the relationships among factor scores for motor and cognitive impairment Voluntary components of motor performance were found to be significantly correlated with verbal shortterm memory disturbances r = −0361 P = 003 with tests of executive functions more dependent on motor performance r = 0640 P  001 and also with tests of executive functions less dependent on motor performance r = 0461 P  001 Involuntary components did not correlate significantly with any part of cognitive performanceThe authors wish to thank Prof David Craufurd for his helpful comments This study was supported by a grant from the Czech Ministry of Health reg No IGA MZ CR NR89374 and NR/92153 and from Czech Ministry of Education Research Program MSM0021620849 and MSM 0021620864

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