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Title of Journal: J Neurol

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Abbravation: Journal of Neurology

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D. Steinkopff-Verlag

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DOI

10.1002/rsa.20488

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1432-1459

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A clinical radiological and outcome study of stat

Authors: J Kalita P P Nair Usha Kant Misra
Publish Date: 2009/09/03
Volume: 257, Issue: 2, Pages: 224-229
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Abstract

The objective of this study is to evaluate the clinical and radiological characteristics and the outcome of status epilepticus SE 117 consecutive patients with SE were evaluated including their demographics history of epilepsy antiepileptic drug AED default comorbidities SE type and duration The study included 22 children 77 adults and 18 elderly patients with SE Blood counts serum chemistry ECG cranial MRI cerebrospinal fluid and EEG were done Patients were treated with IV phenytoin valproate lorazepam or diazepam as per a fixed protocol and responses to first and second drugs were noted Death during hospital was recorded The etiology of SE was infection in 538 drug default in 79 metabolic in 145 stroke in 128 and miscellaneous in 11 of patients 923 of patients had convulsive and 77 nonconvulsive SE Cranial MRI was abnormal in 62 Infection as an etiology was more common in children drug default and metabolic causes in adults and stroke in adults and elderly Following first AED SE was controlled in 50 30 of patients remained refractory to second AED which was related to duration of SE and mortality 29 patients died and death was higher in elderly 44 compared to children 14 Acute symptomatic SE is more common in developing countries Refractory SE is associated with SE duration and mortality

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