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Title of Journal: J Neurol

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Abbravation: Journal of Neurology

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Springer Berlin Heidelberg

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DOI

10.1016/j.ahj.2010.09.021

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1432-1459

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Cortical thinning in drugnaive Parkinson’s diseas

Authors: ChunYan Luo Wei Song Qin Chen Jing Yang QiYong Gong HuiFang Shang
Publish Date: 2016/08/02
Volume: 263, Issue: 10, Pages: 2114-2119
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Abstract

To shed more light on the contribution of brain structural changes to PDrelated depressive symptoms this study conducted cortical thickness analysis in drugnaive PD patients with and without depression We recruited 27 PD patients with depression PDDep 29 PD patients without depression PDNDep and 56 normal controls T1 weighted magnetic resonance imaging and surfacebased morphometric analyses were performed to examine morphometric abnormalities in PD patients and their relationship to depression We found decreased thickness in the left prefrontal cortex in PDDep group compared with PDNDep group No significant difference was found between PD patients and controls In addition we found there is a trend of inverse correlation between the structural changes and the score of depressive symptom in depressed PD patients This study demonstrates that cortical thinning in prefrontal area in drugnaive PD patients with depression and highlights the critical role of prefrontal region in the depression associated with PD

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