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Title of Journal: J Neurol

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Abbravation: Journal of Neurology

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Springer Berlin Heidelberg

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1432-1459

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Low testosterone and myasthenia gravis in males a

Authors: Julia Pakpoor Raph Goldacre Michael J Goldacre
Publish Date: 2016/10/24
Volume: 263, Issue: 12, Pages: 2547-2548
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Abstract

A disease of ‘young women and old men’ myasthenia gravis MG exhibits a bimodal distribution in age with a peak in the second and third decades of life with a female predominance and a later peak in the sixthtoeighth decades of life with a male predominance 1 A role for low testosterone in influencing MG risk in males is suggested by the fact that the agedependent risk of MG in males coincides with an agerelated decline in male testosterone levels 2 Exploration of a role of testosterone has previously been limited to one case report of hypergonadotropic hypogonadism and MG 3 We aimed to investigate an association between testicular hypofunction TH as a proxy for low testosterone levels and subsequent MG risk in malesThe use of these data sets was approved by the English National Research Ethics Service ref 04/Q2006/176 The building of the linked data sets and the development of the analytical software used to study disease associations were funded by the English National Institute for Health Research This study had no specific funding The funder had no role in study design data collection data analysis data interpretation writing of the report or the decision to submit for publication The views expressed in the article do not necessarily reflect those of the funding body

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