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Title of Journal: J Neurol

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Abbravation: Journal of Neurology

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Springer Berlin Heidelberg

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DOI

10.1016/0962-8479(95)90468-9

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1432-1459

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The impact of subthalamic deep brain stimulation o

Authors: Catharine J Lewis Franziska Maier Nina Horstkötter Carsten Eggers Veerle VisserVandewalle Elena Moro Mateusz Zurowski Jens Kuhn Christiane Woopen Lars Timmermann
Publish Date: 2014/11/09
Volume: 262, Issue: 2, Pages: 337-345
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Abstract

To study the caregivers’ perception of their own wellbeing 1 year after subthalamic deep brain stimulation STNDBS surgery in Parkinson’s disease PD patients using a qualitative and quantitative approach 25 patients and caregivers living together in partnerships were examined before and at 3month and 1year followup FU after STNDBS surgery Semistructured FU interviews concerning caregivers’ own wellbeing under STNDBS were conducted and analyzed caregivers were accordingly assigned to positive or negative outcome groups Quality of life QoL depression apathy and anxiety of caregivers and patients were measured These quantitative data were compared to the 1year FU interview outcomes Multiple comparisons analyzed caregiver group assignments based on these measurements Logistic regression was used to find predictors Additionally patients’ mood ratings were used in multiple comparisons with caregivers’ subjective outcome to analyze the interaction of patient and caregiver ratings At 3month FU caregivers were more indecisive concerning their own wellbeing than at 1year FU At 1year FU caregivers from the negative group had greater depression anxiety and lower QoL ratings They were significantly older compared to the positive group Patients’ depression showed significantly stronger improvement in the positive outcome group Patients’ apathy and depression ratings were significant covariates of caregivers’ QoL Our results show that at 1year FU over 50  of the caregivers rated their subjective wellbeing as negative Especially older and more depressed caregivers are at risk These caregivers and their partners should be monitored more closely to identify possible problems and help them adapt following surgeryThis work was supported by the German Ministry of Education and Research BMBF and by the Canadian Institute of Health Research grant number 01GP0806 The study was part of the international and interdisciplinary project “Ethical Legal and Social Aspects of Deep Brain Stimulation ELSADBS” http//geschichteethikukkoelnde/forschungsstelleethik/forschung1/elsadbs CJL FM and LT gratefully report funding by the German Parkinson’s disease foundation Deutsche Parkinson Vereinigung eV dPVC Lewis reports no disclosures F Maier reports no disclosures N Horstkötter reports no disclosures C Eggers has received speaker’s honoraria from Medtronic Inc V VisserVandewalle reports no disclosures E Moro has received honoraria from Medtronic Boston Medical and UCB for consulting services and lecturing in the past 12 months M Zurowski reports no disclosures J Kuhn has received honoraria from AstraZeneca Lilly Lundbeck and Otsuka Pharma for lecturing at conferences and financial support to travel J Kuhn received financial support for IITDBS studies not the present investigation from Medtronic GmbH Meerbusch Germany C Woopen reports no disclosures L Timmermann is consultant for Medtronic Inc Boston Scientific Bayer Healthcare UCB Schwarz Pharma received honoraria in symposia sponsored by TEVA Pharma Lundbeck Pharma Bracco Gianni PR Medas Pharma UCB Schwarz Pharma Desitin Pharma Boehringer Ingelheim GlaxoSmithKline Eumecom Orion Pharma Medtronic Boston Scientific Cephalon Abott GE Medical The institution of Prof Timmermann not Prof Timmermann himself received funding by the German Research Foundation DFG via the Clinical Research Group 219 the German Ministry of Education and Research BMBF Manfred und Ursula Müller Stiftung Klüh Stiftung Hoffnungsbaum e V NBIA DISORDERS SOCIETY USA the medical faculty of the University of Cologne via the “Köln Fortune program” Medtronic Inc and the German Parkinson Foundation Deutsche Parkinson Vereinigung

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