Authors: Paulo Bugalho Joaquim Alves da Silva Bernardo Neto
Publish Date: 2010/08/09
Volume: 258, Issue: 1, Pages: 50-55
Abstract
We aimed to characterize the clinical features associated with REM sleep behaviour disorder RBD in early stage Parkinson’s disease PD Presence of clinical RBD was determined according to ICSD minimal clinical criteria and a validated RBD questionnaire We registered time of appearance of RBD symptoms in relation to PD onset and the occurrence of RBD symptoms in the past in nonRBD patients RBD and nonRBD groups were compared in terms of motor and cognitive dysfunction The same comparisons were made between patients who reported RBD symptoms at some point in time including those nonRBD patients that reported occurrence of RBD symptoms in the past and those who did not RBDS and nonRBDS respectively We assessed 75 patients Fortyone 55 patients presented with RBD 19 beginning before PD onset Five nonRBD patients reported having had RBD symptoms in the past There were no significant differences between RBD and nonRBD patients RBDS group presented a significantly higher proportion of nontremor motor subtype compared to nonRBDS patients Our results suggest that RBD is very frequent in the early stages of PD In some patients RBD symptoms could have disappeared before or in the first years after motor disturbance onset Nontremor motor subtype was related to RBD symptoms history rather than to the presence of RBD clinical criteria at time of evaluation suggesting that the physiopathological changes that cause the association with motor status could remain in spite of symptom fluctuation
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