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Title of Journal: J Neurol

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Abbravation: Journal of Neurology

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Springer-Verlag

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DOI

10.1016/0014-3057(81)90150-6

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1432-1459

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Vascular risk factors are associated with faster d

Authors: Kazumasa Kume Haruo Hanyu Tomohiko Sato Kentaro Hirao Soichiro Shimizu Hidekazu Kanetaka Hiofumi Sakurai Toshihiko Iwamoto
Publish Date: 2011/02/17
Volume: 258, Issue: 7, Pages: 1295-1303
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Abstract

We investigated the effects of cardiovascular risk factors such as hypertension diabetes mellitus and hypercholesterolemia on longitudinal regional cerebral blood flow rCBF changes in Alzheimer’s disease AD We followed 68 outpatients with probable AD for an average of 40 months They were divided into three groups based on no n = 24 single n = 27 and multiple n = 17 vascular risk factors We assessed longitudinal changes on the MiniMental State Examination Functional Assessment Staging scores and in rCBF deficits using repeated single photon emission computed tomography SPECT using Nisopropylp123I iodoamphetamine During followup the multiple vascular risk factor group showed faster cognitive and functional decline than the no and single vascular risk factor groups When compared with the initial SPECT the followup SPECT showed a significant rCBF reduction in widespread regions including the parietotemporal frontal and limbic lobes in the multiple and single vascular risk factor groups while there was rCBF reduction in small scattered regions of the temporoparietal lobe in the no vascular risk factor group Multiple vascular risk factors are associated with a greater rate of decline in cognition function and rCBF in patients with AD Our results highlight the contribution of vascular risk factors on the progression of ADWe thank Professor K Koizumi of the Department of Nuclear Medicine Tokyo Medical University for his support and technical assistance We are also grateful to Assistant Professor Edward F Barroga and Professor J Patrick Barron of the Department of International Medical Communications of Tokyo Medical University for their review of the manuscript

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