Authors: Gardenia C G Militão Daniel P Bezerra Claudia Pessoa Manoel Odorico de Moraes Flavio A F da Ponte Mary Anne S Lima Edilberto R Silveira Letícia V CostaLotufo
Publish Date: 2006/12/02
Volume: 61, Issue: 2, Pages: 196-199
Abstract
The purpose of this study was to investigate the antiproliferative activity of 239trimethoxypterocarpan a known pterocarpan with cytotoxic activity against many tumor cell lines in a panel of four leukemia cell lines HL60 Molt4 Jurkat and K562 and on human peripheral blood mononuclear cells PBMC The pterocarpan showed IC50 ranging from 01 to 05 μg/ml at leukemic cells after 72 h of incubation with K562 being the most resistant cell line This compound seemed to be selective to tumor cell lines since at a concentration of 10 μg/ml after 72 h it only reduced 19 of viable peripheral mononuclear cellsWe wish to thank CNPq Instituto Claude Bernard FUNCAP BNB/FUNDECI and FINEP for the financial support in the form of grants and fellowship awards The authors also thank the National Cancer Institute Bethesda MD USA for the donation of the tumor cell lines used in this study The authors thank Silvana França dos Santos and Maria de Fátima Teixeira for technical assistance
Keywords: