Journal Title
Title of Journal: J Nat Med
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Abbravation: Journal of Natural Medicines
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Authors: Arunachalam Muthuraman Nirmal Singh Amteshwar S Jaggi
Publish Date: 2010/12/10
Volume: 65, Issue: 2, Pages: 282-292
Abstract
This study was designed to investigate the therapeutic potential of hydroalcoholic extracts of Acorus calamus AC in tibial and sural nerve transection TSTinduced neuropathic pain in rats The hot plate paw heat allodynia acetone drop and pinprick tests were performed to assess the degree of heat hyperalgesia heat and cold allodynia and mechanical hyperalgesia respectively at different time intervals ie day 0 1 3 6 9 12 15 18 and 21 The tissue superoxide anion and total calcium were measured as markers of oxidative stress Tissue myeloperoxidase activity was measured as a specific marker of inflammation Histopathological evaluation was also performed in the nervous tissue to assess the axonal degeneration Pregabalin served as positive control in this study TST in rats significantly induced thermal hyperalgesia and allodynia mechanical hyperalgesia and increased the levels of superoxide anion total calcium and myeloperoxidase MPO activity Moreover significant histological changes were also observed Oral administration of AC hydroalcoholic extract 100 and 200 mg/kg for 14 days attenuated TSTinduced behavioral biochemical and histological changes Acorus calamus has ameliorative potential in TSTinduced painful neuropathy and this effect may be attributed to its multiple actions including antiinflammatory antioxidant and neuroprotective actionsThe authors are grateful to the Department of Pharmaceutical Sciences and Drug Research Punjabi University Patiala India for supporting this study and providing technical facilities for the work The authors also acknowledge the financial support from Council of Scientific and Industrial Research CSIR through senior research fellowship SRF
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- Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
- Rapid analysis of 56 pesticide residues in natural medicines by GC/MS with negative chemical ionization
- Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats
- Manadodioxans A−E: polyketide endoperoxides from the marine sponge Plakortis bergquistae
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