Journal Title
Title of Journal: J Nat Med
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Abbravation: Journal of Natural Medicines
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Authors: Susumu Kohno Tomiyasu Murata Ayumi Sugiura Chihiro Ito Mehrdad Iranshahi Kiyomi Hikita Norio Kaneda
Publish Date: 2011/01/19
Volume: 65, Issue: 2, Pages: 353-359
Abstract
It is well known that inflammation is associated with various neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease An inflammatory mediator nitric oxide NO is produced by inducible NO synthase iNOS in microglia and seems to be one of the possible causes of neurodegeneration Several natural and synthetic compounds which exert antiinflammatory effects by inhibiting NO production have been reported to date The aim of this work was to investigate whether any of the 6 terpenoid coumarins methyl galbanate galbanic acid farnesiferol A badrakemone umbelliprenin and aurapten isolated from Ferula szowitsiana DC have inhibitory activity against NO production in RAW2647 mouse macrophage cells stimulated with lipopolysaccharide LPS and interferonγ IFNγ Of the 6 terpenoid coumarins tested methyl galbanate significantly decreased NO production in LPS/IFNγstimulated RAW2647 cells In the presence of methyl galbanate LPS/IFNγinduced iNOS mRNA expression was significantly decreased to 52 of the level found with LPS/IFNγ stimulation alone Methyl galbanate slightly attenuated COX2 mRNA expression Using the RAW2647tsAM5NE coculture system we showed that methyl galbanate protected neuronally differentiated tsAM5NE cells from NOinduced cell death by inhibiting the production of NO Our finding suggests that methyl galbanate may be useful for developing a new drug against neurodegenerative diseases
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- Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance
- A novel steroidal alkaloid from Fritillaria shuchengensis
- Comparative cytotoxicity of 2,3,9-trimethoxypterocarpan in leukemia cell lines (HL-60, Jurkat, Molt-4, and K562) and human peripheral blood mononuclear cells
- Patchouli alcohol: in vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth.
- A simple and selective detection method for aristolochic acid in crude drugs using solid-phase extraction
- A simple and selective detection method for aristolochic acid in crude drugs using solid-phase extraction
- Two new flavonoids from Centella asiatica (Linn.)
- Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals
- Antioxidative activity of the flower of Torenia fournieri
- Cyclic diarylheptanoids as inhibitors of NO production from Acer nikoense
- Morphological, genetic, and chemical polymorphism of Curcuma kwangsiensis
- Chemical and biologically active constituents of Pteris multifida
- Protective effects of an acidic polysaccharide isolated from fruiting bodies of Ganoderma lucidum against murine hepatic injury induced by Propionibacterium acnes and lipopolysaccharide
- Absorptive constituents and their metabolites in drug-containing urine samples from Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction
- Antioxidant activity of red pigments from the lichens Lethariella sernanderi , L. cashmeriana , and L. sinensis
- Three new megastigmanes from the leaves of Annona muricata
- Induction of melanogenesis by 4′- O -methylated flavonoids in B16F10 melanoma cells
- Cesdiurins I–III, steroidal saponins from Cestrum diurnum L.
- Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
- Rapid analysis of 56 pesticide residues in natural medicines by GC/MS with negative chemical ionization
- Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats
- Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats
- Manadodioxans A−E: polyketide endoperoxides from the marine sponge Plakortis bergquistae
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