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Title of Journal: J Nat Med

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Abbravation: Journal of Natural Medicines

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Springer Japan

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DOI

10.1016/0022-2852(75)90175-7

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1861-0293

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Oxomollugin a potential inhibitor of lipopolysacc

Authors: Hiroshi Morita Hitomi Nishino Yuki Nakajima Yoshiaki Kakubari Asami Nakata Jun Deguchi Alfarius Eko Nugroho Yusuke Hirasawa Toshio Kaneda Yoko Kawasaki Yukihiro Goda
Publish Date: 2015/07/01
Volume: 69, Issue: 4, Pages: 608-611
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Abstract

Mollugin a naphthoquinone derivative was reported to possess various biological activities such as antiinflammatory and antitumor activity Mollugin isolated from Rubia tinctorum roots inhibited lipopolysaccharideinduced nitric oxide NO production in RAW2647 macrophages However mollugin synthesized for further investigation of its antiinflammatory mechanism showed weak activity in addition to unstable assay results From the result of analysis on a degradation product of mollugin oxomollugin was found to be the main active substance of mollugin degradation showing a potent inhibitory activity on NOproduction including nuclear factor kappa B signals

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