Journal Title
Title of Journal: J Nat Med
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Abbravation: Journal of Natural Medicines
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Authors: Hiroaki Kiyohara Chikara Ichino Yuka Kawamura Takayuki Nagai Noriko Sato Haruki Yamada
Publish Date: 2011/06/14
Volume: 66, Issue: 1, Pages: 55-61
Abstract
During the screening of antiinfluenza virus substances from traditional herbal medicines the methanol extract from the leaves of Pogostemon cablin Benth showed potent in vitro antiviral activity 998 inhibition at a concentration of 10 μg/mL against influenza virus A/PR/8/34 H1N1 The antiinfluenza virus principle was isolated from the hexanesoluble fraction through solvent fractionation repeated silica gel column chromatography and reversedphase HPLC The major active principle was a volatile substance that was identified as a sesquiterpene patchouli alcohol 1 on the basis of its spectral analyses When antiinfluenza virus activity against A/PR/8/34 was evaluated by the plaque forming assay patchouli alcohol reduced the number of plaques by 75 at 2 μg/mL and 89 at 10 μg/mL Patchouli alcohol showed dosedependent antiinfluenza virus activity and its IC50 value was estimated to be 2635 μM Although 11 different sesquiterpenes were tested for antiviral activity against influenza virus A/PR/8/34 no or negligible activity was observed except for patchouli alcohol Patchouli alcohol did not show antiinfluenza virus activity against A/Guizhou/54/89 H3N2 but showed weak activity against B/Ibaraki/2/85 IC50 = 4082 μM Patchouli alcohol did not show inhibitory activity against influenza virus neuraminidaseThe authors thank the Takasago International Corporation Tokyo Japan for kind gifts of standard sesquiterpenes A part of the present work was supported by The 21st Century COE Program Ministry of Education Culture Sports Science and Technology of Japan
Keywords:
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