Emphasis Type="Italic"Morinda citrifolia/Emphas

Authors: Shinichi Harada Wakako FujitaHamabe Kohei Kamiya Yoshiyuki Mizushina Toshiko Satake Shogo Tokuyama

Publish Date: 2010/06/24

Volume: 64, Issue: 4, Pages: 468-473

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Abstract

Fruit juice of Morinda citrifolia Noni juice is a wellknown health drink and has various pharmacological properties including antioxidant and antiinflammatory effects We have hitherto found the protective effect of Noni juice on brain damage caused by ischemic stress in mice In addition we also recently reported that regulation of postischemic glucose intolerance might be important for good prognosis Here we focused on the effect of Noni juice on the development of the postischemic glucose intolerance as a cerebral protective mechanism Noni juice was obtained from the mature fruit grown in Okinawa about 15 L/4 kg of fruit 100 ONJ Male ddY mice were given 10 ONJ in drinking water for 7 days Then mice were subjected to 2 h of middle cerebral artery occlusion MCAO Ingestion of 10 ONJ suppressed the development of neuronal damage after MCAO Interestingly glucose intolerance observed on the 1st day after MCAO completely disappeared after 10 ONJ administration Furthermore ONJ treatment significantly increased serum insulin levels much further than the control group on the 1st day while serum adiponectin levels were not affected at all These results suggest that ONJ could facilitate insulin secretion after ischemic stress and may attenuate the development of glucose intolerance These mechanisms may contribute to the neuronal protective effect of ONJ against ischemic stressParts of this study were supported by grantsinaid and special coordination funds from the Ministry of Education Culture Sports Science and Technology for Young Scientists B 30382328 Kobe Gakuin University Joint Research B and “Academic Frontier” Project Cooperative Research Center of Life Sciences

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