Plasma folate and risk of colorectal cancer in a n

Authors: Tetsuya Otani Motoki Iwasaki Shizuka Sasazuki Manami Inoue Shoichiro Tsugane The Japan Public Health Centerbased Prospective Study Group

Publish Date: 2007/10/18

Volume: 19, Issue: 1, Pages: 67-74

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Abstract

There is some evidence that folate may prevent colorectal cancer by stabilizing DNA sufficiently and methylating DNA appropriately Plasma folate is a good marker to assess folate status in the body but it has not been adequately examined in prospective epidemiologic studies We investigated the association between plasma folate and the risk of colorectal cancer in a nested casecontrol studyDuring a 115year followup 375 newly diagnosed colorectal cancers were identified in a cohort of 38373 adults who had returned their baseline questionnaires and provided blood samples Two controls for each case were selected from the cohort The odds ratios OR and 95 confidence intervals CI of colorectal cancer for plasma folate was estimated using the conditional logistic regression model adjusted for potential confounding factorsPlasma folate was not associated with the risk of colorectal cancer in either men or women although a small reduction of OR in men was observed in the second OR 070 95 CI 037–13 the third OR 072 95 CI 038–13 and the highest quartiles OR 086 95 CI 045–16 without a dose–response relationship P for trend 088 A similar association was observed in the risk of colon or rectal cancer No statistical interaction with the risk of colorectal cancer was observed between plasma folate and alcohol consumptionWe are grateful to all the staff members in each study area for their painstaking efforts in conducting the baseline and followup surveys We are also indebted to the Iwate Aomori Ibaraki Niigata Osaka Kochi Nagasaki and Okinawa Cancer Registries for providing their incidence data as well as to Tomohiro Shintani Hidehito Takenaka and Kyoko Suzuki for their valuable technical assistance We also thank Drs Edward Giovannucci and Walter C Willett for their helpful commentsMembers of The Japan Public Health Centerbased Prospective Study Group are S Tsugane M Inoue T Sobue T Hanaoka National Cancer Center Tokyo J Ogata S Baba T Mannami A Okayama National Cardiovascular Center Suita K Miyakawa F Saito A Koizumi Y Sano I Hashimoto Iwate Prefectural Ninohe Public Health Center Ninohe Y Miyajima N Suzuki S Nagasawa Y Furusugi Akita Prefectural Yokote Public Health Center Yokote H Sanada Y Hatayama F Kobayashi H Uchino Y Shirai T Kondo R Sasaki Y Watanabe Y Miyagawa Nagano Prefectural Saku Public Health Center Saku Y Kishimoto E Takara T Fukuyama M Kinjo M Irei H Sakiyama Okinawa Prefectural Chubu Public Health Center Okinawa K Imoto H Yazawa T Seo A Seiko F Ito F Shoji Katsushika Public Health Center Tokyo A Murata K Minato K Motegi T Fujieda Ibaraki Prefectural Mito Public Health Center Mito K Matsui T Abe M Katagiri M Suzuki Niigata Prefectural Kashiwazaki and Nagaoka Public Health Center Kashiwazaki and Nagaoka M Doi A Terao Y Ishikawa Kochi Prefectural Chuohigashi Public Health Center Tosayamada H Sueta H Doi M Urata N Okamoto F Ide Nagasaki Prefectural Kamigoto Public Health Center Arikawa H Sakiyama N Onga H Takaesu Okinawa Prefectural Miyako Public Health Center Hirara F Horii I Asano H Yamaguchi K Aoki S Maruyama M Ichii Osaka Prefectural Suita Public Health Center Suita S Matsushima S Natsukawa Saku General Hospital Usuda M Akabane Tokyo University of Agriculture Tokyo M Konishi K Okada Ehime University Matsuyama H Iso Y Honda Tsukuba University Tsukuba H Sugimura Hamamatsu University Hamamatsu Y Tsubono Tohoku University Sendai M Kabuto National Institute for Environmental Studies Tsukuba S Tominaga Aichi Cancer Center Research Institute Nagoya M Iida W Ajiki Osaka Medical Center for Cancer and Cardiovascular Disease Osaka S Sato Osaka Medical Center for Health Science and Promotion Osaka N Yasuda Kochi Medical School Nankoku S Kono Kyushu University Fukuoka K Suzuki Research Institute for Brain and Blood Vessels Akita Akita Y Takashima Kyorin University Mitaka E Maruyama Kobe University Kobe the late M Yamaguchi Y Matsumura S Sasaki S Watanabe National Institute of Health and Nutrition Tokyo and T Kadowaki Tokyo University Tokyo

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