Birth size and survival in breast cancer patient

Authors: Ulla Sovio Rebecca Jones Isabel dos Santos Silva Ilona Koupil

Publish Date: 2013/05/31

Volume: 24, Issue: 9, Pages: 1643-1651

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Abstract

Previous studies suggest that larger birth size is associated with a higher breast cancer incidence but studies on birth measures and mortality in breast cancer cases are scarce This study investigates survival of women after breast cancer diagnosis n = 437 in the Uppsala Birth Cohort born in 1915–1929Cox regression was used to analyze mortality from any cause after a breast cancer diagnosis Birth measures including gestational age GA birth weight BW BW for GA birth length and ponderal index PI were converted to standard deviation SD scores and all analyses were adjusted for age and calendar time at diagnosis Analyses were performed with and without adjustment for other birth measures reproductive history and adult socioeconomic positionIn fully adjusted analyses one SD increase in GA was associated with 17  95  confidence interval CI 6–26  lower mortality and one SD increase in BW was associated with 29  7–56  higher mortality PI showed a weaker trend in the same direction hazard ratio = 116 95  CI 103–130

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