Journal Title
Title of Journal: Cancer Causes Control
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Abbravation: Cancer Causes & Control
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Publisher
Springer Netherlands
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Authors: Maria Benevolo Irene Terrenato Marcella Mottolese Ferdinando Marandino Mariantonia Carosi Francesca Rollo Livia Ronchetti Paola Muti Luciano Mariani Stefano Sindico Giuseppe Vocaturo Amina Vocaturo
Publish Date: 2011/03/19
Volume: 22, Issue: 6, Pages: 869-875
Abstract
The study aimed to assess the clinical utility in identifying CIN2 or worse CIN2+ of the Pretect HPVProofer test for E6/E7 mRNA detection in Hybrid Capture 2 HC2positive patients who underwent colposcopy In particular the study analyzed the mRNA test performance as the third test in a subgroup of HC2+ patients with less severe than highgrade squamous intraepithelial lesions HSIL− We analyzed 464 cervicovaginal samples by liquidbased cytology LBC and PreTect HPVProofer Moreover 231 patients also had a biopsy at baseline and 75 with HSIL− were followed up within 2 years by LBC colposcopy and histology when indicated The highest sensitivity for CIN2+ belonged to the mRNA compared to LBC at the HSIL+ threshold 72 vs 58 whereas the LBC showed the highest specificity and positive predictive value PPV 99 and 93 vs 73 and 39 respectively Focusing on the 408 HSIL− patients the mRNA positivity was significantly more associated with CIN2+ than CIN2− lesions p 00001 Moreover among the 75 HSIL− followed up patients the mRNA displayed high longitudinal Specificity 89 even if the sensitivity and the PPV were low 50 and 20 respectively The present data suggest that the mRNA test may have a diagnostic and a potentially prognostic role in HC2+/HSIL− patientsWe would like to thank Michael Kenyon for his formal revision of the manuscript and Maria Assunta Fonsi for her secretarial assistance This study was supported by the New Idea Award Group in Gynecological Oncology of the Regina Elena Cancer Institute by the Italian Ministry of Health and by Lega Italiana per la Lotta contro i Tumori
Keywords:
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Other Papers In This Journal:
- Risk factors for lung cancer: a case–control study in Hong Kong women
- Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC
- Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based prospective study
- Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk
- Association of genetic variation in IKZF1 , ARID5B , and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children
- Sleep duration and cancer risk in women
- Variations in breast cancer incidence per decade of life (Goiânia, GO, Brazil): 16-year analysis
- Physical activity and endometrial cancer in a population-based case–control study
- Androgen deprivation therapy and the risk of colorectal cancer in patients with prostate cancer
- Abuse victimization and risk of breast cancer in the Black Women’s Health Study
- Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies
- Joint effects between five identified risk variants, allergy, and autoimmune conditions on glioma risk
- Risk factors for young-onset colorectal cancer
- Factors that influence mammography use and breast cancer detection among Mexican-American and African-American women
- Birth size and survival in breast cancer patients from the Uppsala Birth Cohort Study
- Availability and utility of body mass index for population-based cancer surveillance
- Dietary lipids and endometrial cancer: the current epidemiologic evidence
- Exposure to sunlamps, tanning beds, and melanoma risk
- Green tea and coffee consumption and its association with thyroid cancer risk: a population-based cohort study in Japan
- Association between high-sensitivity C-reactive protein (hsCRP) and change in mammographic density over time in the SWAN mammographic density subcohort
- Obesity and head and neck cancer risk and survival by human papillomavirus serology
- Statins and pancreatic cancer risk: a nested case–control study
- Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males
- A bupropion smoking cessation clinical trial for cancer patients
- Obesity, ethnicity, and quality of life among breast cancer survivors and women without breast cancer: the long-term quality of life follow-up study
- Prevalence of HPV types in cervical specimens from an integrated healthcare delivery system: baseline assessment to measure HPV vaccine impact
- Genetic variation in estrogen and progesterone pathway genes and breast cancer risk: an exploration of tumor subtype-specific effects
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