A bupropion smoking cessation clinical trial for c

Authors: Robert A Schnoll Elisa Martinez Kristina L Tatum Dorothy M Weber Natalie Kuzla Marcella Glass John A Ridge Corey Langer Curtis Miyamoto E Paul Wileyto Frank Leone

Publish Date: 2010/01/20

Volume: 21, Issue: 6, Pages: 811-820

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Abstract

This doubleblind placebocontrolled trial randomized 246 cancer patients to 9 weeks of placebo or bupropion stratifying by pretreatment depression symptoms In addition all patients received transdermal nicotine and behavioral counseling Primary outcomes were 7day pointprevalence abstinence biochemically confirmed at the end of treatment Week 12 and at 6 months post quit day Week 27 Additional outcomes included withdrawal affect quality of life compliance and side effectsThere was no main effect of bupropion vs placebo on abstinence Odds Ratio OR = 136 95 CI 038–481 p = 64 Patients with depression symptoms reported significantly lower abstinence rates vs patients without depression symptoms OR = 14 95 CI 002–080 p = 03 Bupropion increased abstinence rates vs placebo more for participants with depression vs those without depression symptoms For patients with depression symptoms bupropion reduced withdrawal symptoms and improved quality of life vs placeboFor patients with depression symptoms bupropion increases abstinence rates lowers withdrawal and increases quality of life However abstinence rates among patients with depression symptoms were low vs patients without depression symptoms who exhibited similar abstinence rates when treated with bupropion or transdermal nicotine and counseling alone These results can guide future smoking cessation intervention studies with cancer patientsThe authors would like to thank Ms Jeanne Pomenti for assisting with the preparation of this manuscript This study was funded by grant R01 CA95678 from the National Cancer Institute Transdermal nicotine patches were provided freeofcharge by GlaxoSmithKline All sites provided Institutional Review Board approval All patients provided informed consent for this study

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