Joint effects between five identified risk variant

Authors: Mahboobeh Safaeian Preetha Rajaraman Patricia Hartge Meredith Yeager Martha Linet Mary Ann Butler Avima M Ruder Mark P Purdue Ann Hsing Laura BeaneFreeman Jane A Hoppin Demetrius Albanes Stephanie J Weinstein Peter D Inskip Alina Brenner Nathaniel Rothman Nilanjan Chatterjee Elizabeth M Gillanders Stephen J Chanock Sophia S Wang

Publish Date: 2013/08/01

Volume: 24, Issue: 10, Pages: 1885-1891

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Abstract

Common variants in two of the five genetic regions recently identified from genomewide association studies GWAS of risk of glioma were reported to interact with a history of allergic symptoms In a pooled analysis of five epidemiologic studies we evaluated the association between the five GWAS implicated gene variants and allergies and autoimmune conditions AIC on glioma risk 851 adult glioma cases and 3977 controls We further evaluated the joint effects between allergies and AIC and these gene variants on glioma risk Risk estimates were calculated as odds ratios OR and 95  confidence intervals 95  CI adjusted for age gender and study Joint effects were evaluated by conducting stratified analyses whereby the risk associations OR and 95  CI with the allergy or autoimmune conditions for glioma were evaluated by the presence or absence of the ‘atrisk’ variant and estimated p interaction by fitting models with the main effects of allergy or autoimmune conditions and genotype and an interaction product term between them Four of the five SNPs previously reported by others were statistically significantly associated with increased risk of glioma in our study rs2736100 rs4295627 rs4977756 and rs6010620 rs498872 was not associated with glioma in our study Reporting any allergies or AIC was associated with reduced risks of glioma allergy adjusted OR = 071 95  CI 055–091 AIC adjusted OR = 065 95  CI 047–090 We did not observe differential association between allergic or autoimmune conditions and glioma by genotype and there were no statistically significant p interactions Stratified analysis by glioma grade low and high grade did not suggest risk differences by disease grade Our results do not provide evidence that allergies or AIC modulate the association between the four GWASidentified SNPs examined and risk of gliomaThe study was funded by Intramural Research Program of the National Cancer Institute and the National Institute for Occupational Safety and Health It was been funded in whole or in part with federal funds from the National Cancer Institute under contract N01CO12400 The funding source for AHS is from the Intramural Program of NIEHS  AHS Data release P1REL0506 02 We are indebted to the scientific and field efforts of Tim Sheehy Laurie Burdette Aurelie Vogt Annelie Landgren Zhaoming Wang Arti Aranasi Michelle Brotzman Lisa Newman and Peter Hui

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