Prediagnostic concentrations of plasma genistein a

Authors: Ruth C Travis Naomi E Allen Paul N Appleby Alison Price Rudolf Kaaks Jenny ChangClaude Heiner Boeing Krasimira Aleksandrova Anne Tjønneland Nina Føns Johnsen Kim Overvad J Ramón Quirós Carlos A González Esther MolinaMontes Maria José Sánchez Nerea Larrañaga José María Huerta Castaño Eva Ardanaz KayTee Khaw Nick Wareham Antonia Trichopoulou Tina Karapetyan Snorri Bjorn Rafnsson Domenico Palli Vittorio Krogh Rosario Tumino Paolo Vineis H Bas BuenodeMesquita Pär Stattin Mattias Johansson Veronika Fedirko Teresa Norat Afshan Siddiq Elio Riboli Timothy J Key

Publish Date: 2012/05/22

Volume: 23, Issue: 7, Pages: 1163-1171

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Abstract

Data from prospective epidemiological studies in Asian populations and from experimental studies in animals and cell lines suggest a possible protective association between dietary isoflavones and the development of prostate cancer We examined the association between circulating concentrations of genistein and prostate cancer risk in a case–control study nested in the European Prospective Investigation into Cancer and NutritionConcentrations of the isoflavone genistein were measured in prediagnostic plasma samples for 1605 prostate cancer cases and 1697 matched control participants Relative risks RRs for prostate cancer in relation to plasma concentrations of genistein were estimated by conditional logistic regressionPlasma genistein concentrations were not associated with prostate cancer risk the multivariate relative risk for men in the highest fifth of genistein compared with men in the lowest fifth was 100 95   confidence interval 079 127 p linear trend = 082 There was no evidence of heterogeneity in this association by age at blood collection country of recruitment or cancer stage or histological gradeResults from several prospective epidemiological studies of dietary isoflavone or soy intake and prostate cancer risk in Asian populations as well as from experimental studies in animal models and in cell lines suggest a possible protective association between dietary isoflavones and the development of prostate cancer 1 2 3 The contrasting null findings in the majority of observational studies in nonAsian populations have been partly attributed to the typically lower amount of isoflavones consumed in those populations 2 However it is difficult to exclude residual confounding by some other aspect of a traditional Asian lifestyle as an explanation for the apparent protective associations observed in Asian populations

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