Green tea and coffee consumption and its associati

Authors: Takehiro Michikawa Manami Inoue Taichi Shimazu Shizuka Sasazuki Motoki Iwasaki Norie Sawada Taiki Yamaji Shoichiro Tsugane

Publish Date: 2011/05/12

Volume: 22, Issue: 7, Pages: 985-

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Abstract

The anticarcinogenic potential of green tea and coffee might be expected to reduce the risk of thyroid cancer but epidemiological evidence is sparse We examined green tea and coffee consumption in association with thyroid cancer risk in a general Japanese populationWe analyzed data from a prospective cohort of 100507 persons 48802 men 51705 women aged 40–69 Green tea and coffee consumption were assessed via a selfadministered questionnaire During a mean 142year followup we documented 159 thyroid cancer cases 26 in men 133 in women and Cox regression were used to calculated hazard ratios HRsGreen tea consumption was not found to be associated with thyroid cancer risk in general However when women were stratified by menopausal status the multivariable HR for ≥5 cups/day versus 1 cup/day was 166 95 confidence interval CI = 085–323 trend p = 004 in premenopausal women and was 047 95 CI = 023–096 trend p = 006 in postmenopausal women We found no association between coffee consumption and thyroid cancer risk in either sexThe authors thank all staff members in each study area We are indebted to the Aomori Iwate Ibaraki Niigata Osaka Kochi Nagasaki and Okinawa Cancer Registries for providing their incidence data This work was supported by a GrantinAid for Cancer Research from the Ministry of Health Labour and Welfare Japan until 2009 and by Management Expenses Grants from the Government to the National Cancer Center since 2010 It has also supported by a GrantinAid for the ThirdTerm Comprehensive Control Research for Cancer from the Ministry of Health Labour and Welfare Japan and by a GrantinAid from Keio Medical AssociationMembers of the Japan Public Health Centerbased Prospective Study JPHC Study principal investigator S Tsugane Group are S Tsugane M Inoue T Sobue and T Hanaoka National Cancer Center Tokyo J Ogata S Baba T Mannami A Okayama and Y Kokubo National Cardiovascular Center Osaka K Miyakawa F Saito A Koizumi Y Sano I Hashimoto T Ikuta and Y Tanaba Iwate Prefectural Ninohe Public Health Center Iwate Y Miyajima N Suzuki S Nagasawa Y Furusugi and N Nagai Akita Prefectural Yokote Public Health Center Akita H Sanada Y Hatayama F Kobayashi H Uchino Y Shirai T Kondo R Sasaki Y Watanabe Y Miyagawa Y Kobayashi and M Machida Nagano Prefectural Saku Public Health Center Nagano Y Kishimoto E Takara T Fukuyama M Kinjo M Irei and H Sakiyama Okinawa Prefectural Chubu Public Health Center Okinawa K Imoto H Yazawa T Seo A Seiko F Ito F Shoji and R Saito Katsushika Public Health Center Tokyo A Murata K Minato K Motegi T Fujieda and S Yamato Ibaraki Prefectural Mito Public Health Center Ibaraki K Matsui T Abe M Katagiri and M Suzuki Niigata Prefectural Kashiwazaki and Nagaoka Public Health Center Niigata M Doi A Terao Y Ishikawa and T Tagami Kochi Prefectural Chuohigashi Public Health Center Kochi H Sueta H Doi M Urata N Okamoto and F Ide and H Goto Nagasaki Prefectural Kamigoto Public Health Center Nagasaki H Sakiyama N Onga H Takaesu and M Uehara Okinawa Prefectural Miyako Public Health Center Okinawa F Horii I Asano H Yamaguchi K Aoki S Maruyama M Ichii and M Takano Osaka Prefectural Suita Public Health Center Osaka Y Tsubono Tohoku University Miyagi K Suzuki Research Institute for Brain and Blood Vessels Akita Akita Y Honda K Yamagishi S Sakurai and N Tsuchiya Tsukuba University Ibaraki M Kabuto National Institute for Environmental Studies Ibaraki M Yamaguchi Y Matsumura S Sasaki and S Watanabe National Institute of Health and Nutrition Tokyo M Akabane Tokyo University of Agriculture Tokyo T Kadowaki Tokyo University Tokyo M Noda and T Mizoue International Medical Center of Japan Tokyo Y Kawaguchi Tokyo Medical and Dental University Tokyo Y Takashima and Y Yoshida Kyorin University Tokyo K Nakamura Niigata University Niigata S Matsushima and S Natsukawa Saku General Hospital Nagano H Shimizu Sakihae Institute Gifu H Sugimura Hamamatsu University Shizuoka S Tominaga Aichi Cancer Center Research Institute Aichi H Iso Osaka University Osaka M Iida W Ajiki and A Ioka Osaka Medical Center for Cancer and Cardiovascular Disease Osaka S Sato Chiba Prefectural Institute of Public Health Chiba E Maruyama Kobe University Hyogo M Konishi K Okada and I Saito Ehime University Ehime N Yasuda Kochi University Kochi S Kono Kyushu University Fukuoka

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