Sleep duration and cancer risk in women

Authors: Susan Hurley Debbie Goldberg Leslie Bernstein Peggy Reynolds

Publish Date: 2015/04/30

Volume: 26, Issue: 7, Pages: 1037-1045

PDF Link

Abstract

The study population was comprised of 101609 adult females participating in the California Teachers Study All sites of invasive cancer prospectively diagnosed from baseline 1995–1996 through 2011 were identified through linkage to the California Cancer Registry n = 12322 Sitespecific analyses focused on the following cancers breast n = 5053 colorectal n = 983 lung n = 820 melanoma n = 749 and endometrial n = 957 Additionally we evaluated a group of estrogenmediated cancers consisting of breast endometrial and ovarian cancer n = 6458 Sleep duration was based on selfreport of average time sleeping in the year prior to baseline Cox proportional hazard models were used to calculate adjusted hazard ratios and 95  confidence intervals HRs 95  CIPoint estimates for all sites and sitespecific cancers generally were near or below one for short sleepers 6 h/night and above one for long sleepers 10+ h/night confidence intervals however were wide and included unity Compared to average sleepers 7–9 h/night long sleepers had an increased risk of the group of estrogenmediated cancers HR 122 95  CI 097–154 p trend = 004This research was supported by funds provided by The Regents of the University of California California Breast Cancer Research Program Grant Number 16IB0071 and National Cancer Institute Grants R01 CA77398 and K05 CA136967 The opinions findings and conclusions herein are those of the authors and do not necessarily represent those of The Regents of the University of California or any of its programs The collection of cancer incidence data used in this study was supported by the California Department of Public Health as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885 the National Cancer Institute’s Surveillance Epidemiology and End Results Program under contract HHSN261201000036C awarded to the Cancer Prevention Institute of California contract HHSN261201000035C awarded to the University of Southern California and contract HHSN261201000034C awarded to the Public Health Institute and the Centers for Disease Control and Prevention’s National Program of Cancer Registries under agreement 1U58 DP00080701 awarded to the Public Health Institute The ideas and opinions expressed herein are those of the authors and endorsement by the State of California Department of Public Health the National Cancer Institute and the Centers for Disease Control and Prevention or their Contractors and Subcontractors is not intended nor should be inferred We express our appreciation to all the participants in the California Teachers Study and to the researchers analysts and staff who have contributed so much for the success of this research project We also thank Minhthu Le for administrative support and the California Teachers Study Steering Committee members who are responsible for the formation and maintenance of the cohort within which this study was conducted but who did not directly contribute to the current paper Hoda AntonCulver Jessica Clague Christina A Clarke Dennis Deapen Pam HornRoss James V Lacey Jr Yani Lu Huiyan Ma Susan L Neuhausen Hannah Park Rich Pinder Fredrick Schumacher Sophia S Wang and Argyrios Ziogas

Keywords: