Physical activity diabetes and thyroid cancer ri

Authors: Cari M Kitahara Elizabeth A Platz Laura E Beane Freeman Amanda Black Ann W Hsing Martha S Linet Yikyung Park Catherine Schairer Amy Berrington de González

Publish Date: 2012/02/01

Volume: 23, Issue: 3, Pages: 463-471

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Abstract

Although many studies have linked obesity with increased risk of thyroid cancer few have investigated the role of obesityrelated lifestyle characteristics and medical conditions in the etiology of this disease We examined the associations of selfreported physical activity and diabetes history with thyroid cancer risk in a large pooled analysis of prospective cohort studiesData from five prospective studies in the US n = 362342 men 312149 women were coded using standardized exposure covariate and outcome definitions Hazard ratios HR and 95 confidence intervals CI for thyroid cancer were estimated using age as the time metric and adjusting for sex education race marital status cigarette smoking body mass index alcohol intake and cohort Effect modification by other risk factors eg age sex and body mass index and differences by cancer subtype eg papillary follicular were also examinedOver followup median = 105 years 308 men and 510 women were diagnosed with a first primary thyroid cancer Overall subjects reporting the greatest amount of physical activity had an increased risk of the disease HR = 118 95 CI100–139 however this association was restricted to participants who were overweight/obese ≥25 kg/m2 HR = 134 95 CI109–164 as opposed to normalweight 25 kg/m2 HR = 092 95 CI069–122 Pinteraction = 003 We found no overall association between selfreported history of diabetes and thyroid cancer risk HR = 108 95 CI083–140This work was supported in part by the Intramural Research Program of the National Cancer Institute National Institutes of Health Specific to NIHAARP Cancer incidence data from the Atlanta metropolitan area were collected by the Georgia Center for Cancer Statistics Department of Epidemiology Rollins School of Public Health Emory University Cancer incidence data from California were collected by the California Department of Health Services Cancer Surveillance Section Cancer incidence data from the Detroit metropolitan area were collected by the Michigan Cancer Surveillance Program Community Health Administration State of Michigan The Florida cancer incidence data used in this report were collected by the Florida Cancer Data System FCDC under contract with the Florida Department of Health FDOH The views expressed herein are solely those of the authors and do not necessarily reflect those of the FCDC or FDOH Cancer incidence data from Louisiana were collected by the Louisiana Tumor Registry Louisiana State University Medical Center in New Orleans Cancer incidence data from New Jersey were collected by the New Jersey State Cancer Registry Cancer Epidemiology Services New Jersey State Department of Health and Senior Services Cancer incidence data from North Carolina were collected by the North Carolina Central Cancer Registry Cancer incidence data from Pennsylvania were supplied by the Division of Health Statistics and Research Pennsylvania Department of Health Harrisburg Pennsylvania The Pennsylvania Department of Health specifically disclaims responsibility for any analyses interpretations or conclusions Cancer incidence data from Arizona were collected by the Arizona Cancer Registry Division of Public Health Services Arizona Department of Health Services Cancer incidence data from Texas were collected by the Texas Cancer Registry Cancer Epidemiology and Surveillance Branch Texas Department of State Health Services We are indebted to the participants in the NIHAARP Diet and Health Study for their outstanding cooperation We also thank Sigurd Hermansen and Kerry Grace Morrissey from Westat for study outcomes ascertainment and management and Leslie Carroll at Information Management Services for data support and analysis In memory of Dr Arthur Schatzkin visionary investigator who founded the NIHAARP Diet and Health Study

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