Healthrelated quality of life in HIV1infected p

Authors: Camelia Protopopescu Fabienne Marcellin Bruno Spire Marie Préau Renaud Verdon Dominique Peyramond François Raffi Geneviève Chêne Catherine Leport MariaPatrizia Carrieri

Publish Date: 2007/02/01

Volume: 16, Issue: 4, Pages: 577-

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Abstract

The longterm efficacy of Highly Active Antiretroviral Therapies HAART has enlightened the crucial role of healthrelated quality of life HRQL among HIVinfected patients However any analysis of such extensive longitudinal data necessitates a suitable handling of dropout which may correlate with patients–health statusWe analysed the HRQL evolution over 5 years for 1000 patients initiating a protease inhibitor PIcontaining therapy using MOS SF36 physical PCS and mental MCS scores In parallel with a classical separate random effects model we used a joint parameterdependent selection model to account for nonignorable dropoutHRQL evolved according to a twophase pattern characterized by an initial improvement during the year following HAART initiation and a relative stabilization thereafter Immunodepression and selfreported side effects were found to be negative predictors of both PCS and MCS scores Hepatitis C virus coinfection and AIDS clinical stage were found to affect physical HRQL Results were not significantly altered when accounting for dropoutScientific Committee Members of Steering Committee and other members D Costagliola P Dellamonica C Katlama L Meyer M Morin D Salmon A Sobel Project coordination F Collin Events Validation Committee L Cuzin M Dupon X Duval V Le Moing B Marchou T May P Morlat C Rabaud A WaldnerCombernoux Clinical Research Group V Le Moing C LewdenClinical centers Amiens Pr Schmit Angers Dr Chennebault Belfort Dr Faller Besançon Dr Estavoyer Pr Laurent Pr Vuitton Bordeaux Pr Beylot Pr Lacut Pr Le Bras Pr Ragnaud BourgenBresse Dr Granier Brest Pr Garré Caen Pr Bazin Compiègne Dr Veyssier CorbeilEssonne Dr Devidas Créteil Pr Sobel Dijon Pr Portier Garches Pr Perronne Lagny Dr Lagarde Libourne Dr Ceccaldi Lyon Pr Peyramond Meaux Dr Allard Montpellier Pr Reynes Nancy Pr Canton Nantes Pr Raffi Nice Pr Cassuto Pr Dellamonica Orléans Dr Arsac Paris Pr Bricaire Pr Caulin Pr Frottier Pr Herson Pr Imbert Dr Malkin Pr Rozenbaum Pr Sicard Pr Vachon Pr Vildé Poitiers Pr BecqGiraudon Reims Pr Rémy Rennes Pr Cartier SaintEtienne Pr Lucht SaintMandé Pr Roué Strasbourg Pr Lang Toulon Dr Jaureguiberry Toulouse Pr Massip Tours Pr Choutet

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