Authors: Nancy E Mayo Ala’ Aburub MarieJosée Brouillette Ayse Kuspinar Carolina Moriello Ana Maria Rodriguez Susan Scott
Publish Date: 2016/12/17
Volume: 26, Issue: 3, Pages: 601-609
Abstract
To estimate across four health conditions the magnitude of the association between scores derived from the Patient Generated Index PGI and those from fully standardized generic and diseasespecific measures of the HRQL to identify the extent to which the areas generated from the PGI are covered by the content of the fully standardized measuresThe PGI and other generic and diseasespecific measures had been used in four different samples of people stroke n = 222 multiple sclerosis MS n = 185 advanced cancer n = 173 and HIV+ n = 690 Areas nominated on the PGI were harmonized to a standard nomenclature Pearson correlations were estimated between PGI and other measuresData from 1263 people indicated that PGI provided the lowest rating for HRQL across all health conditions The areas nominated differed across conditions with walking/mobility the most common for stroke 42 work/school for MS 62 health for HIV+ 97 and fatigue for cancer 39 Many of the aspects of health included in generic measures were not nominated using the PGI and vice versa The highest correlations between the PGI and other measures were observed for people with MS with correlations between 053 and 059 lowest correlations were observed for people with HIV and cancer ≤033The PGI scores reflect those aspects of quality of life that are important to patients in which they would most value an improvement Heterogeneity in HRQL across health conditions is poorly discriminated using standardized measures A “onesizefitsall” approach to HRQL assessment may not provide the most useful representation of this important constructAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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