Authors: T Nayiager L Anderson A Cranston U Athale R D Barr
Publish Date: 2016/11/24
Volume: 26, Issue: 5, Pages: 1371-1377
Abstract
Children with acute lymphoblastic leukemia ALL the commonest form of cancer in this age group suffer considerable morbidity during treatment with the majority returning to good health soon after therapy has been completed as reflected in healthrelated quality of life HRQL However survivors are at risk of many adverse health outcomes later including obesity measured by body mass index BMI that is compounded by limited physical activity This study examined the HRQL of longterm survivors of ALL and its relationship to BMI and physical activityA cohort of 75 subjects who were more than 10 years from diagnosis was assessed for BMI weight in kg/height in m2 and completed two questionnaires HRQL was measured by the multiattribute preferencebased Health Utilities Index HUI instrument HUI23S415Q designed for selfreport and physical activity was quantified by the Habitual Activity Estimation ScaleThe mean utility scores for overall HRQL HUI2 = 088 HUI3 = 083 were similar to those in the Canadian and US general population segments of equivalent age HUI2 = 086 HUI3 = 085 However the minimum scores HUI2 = 023 HUI3 = −009 revealed a group of survivors with notable disabilities in the attributes of hearing emotion cognition and pain There were no statistically significant correlations between HRQL and BMI or between HRQL and physical activity except for deafness and inactivity on weekdaysThis article does not contain any studies with animals performed by any of the authors The study was approved by the Hamilton Integrated Research Ethics Board Project 105085 that represents Hamilton Health Sciences McMaster University and St Joseph’s Healthcare
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