Authors: Claire F Snyder Amanda L Blackford Toru Okuyama Tatsuo Akechi Hiroko Yamashita Tatsuya Toyama Michael A Carducci Albert W Wu
Publish Date: 2013/03/27
Volume: 22, Issue: 10, Pages: 2685-2691
Abstract
Patientreported outcomes PROs are used increasingly for individual patient management Identifying which PRO scores require a clinician’s attention is an ongoing challenge Previous research used a needs assessment to identify EORTCQLQC30 cutoff scores representing unmet needs This analysis attempted to replicate the previous findings in a new and larger sampleThis analysis used data from 408 Japanese ambulatory breast cancer patients who completed the QLQC30 and Supportive Care Needs SurveyShort Form34 SCNSSF34 Applying the methods used previously SCNSSF34 item/domain scores were dichotomized as no versus some unmet need We calculated area under the receiver operating characteristic curve AUC to evaluate QLQC30 scores’ ability to discriminate between patients with no versus some unmet need based on SCNSSF34 items/domains For QLQC30 domains with AUC ≥ 070 we calculated the sensitivity specificity and predictive value of various cutoffs for identifying unmet needs We hypothesized that compared to our original analysis 1 the same six QLQC30 domains would have AUC ≥ 070 2 the same SCNSSF34 items would be best discriminated by QLQC30 scores and 3 the sensitivity and specificity of our original cutoff scores would be supportedThe findings from our original analysis were supported The same six domains with AUC ≥ 070 in the original analysis had AUC ≥ 070 in this new sample and the same SCNSSF34 item was best discriminated by QLQC30 scores Cutoff scores were identified with sensitivity ≥084 and specificity ≥054
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