Authors: Katherine Moran Stefan Priebe
Publish Date: 2016/02/05
Volume: 25, Issue: 8, Pages: 1897-1902
Abstract
In a randomised controlled trial patients were offered financial incentives to improve their adherence to antipsychotic maintenance medication Compared to a control group without the incentives they had an improved adherence and also better subjective quality of life SQOL after 1 year This paper explores the question as to whether this improvement in SQOL was associated with the amount of money received or with the improved adherence itselfA secondary analysis was performed using data of the experimental group in the trial Adherence was assessed as the percentage of all prescribed longacting antipsychotic injections that were taken by the patient In regression models we tested whether changes in medication adherence and/or the amount of incentives received over the 12month period was associated with SQOL as rated on the DIALOG scaleAdherence changed from 6849 at baseline to 8823 mean difference in adherence = 1959 SD = 1752 The total amount of incentives received within the 1year study period varied between £75 and £735 depending on the treatment cycle and the number of longacting injections taken Improvement in adherence was found to be a significant predictor of better subjective quality of life β = 0014 95 CI 0003–0025 p = 0014 whilst the amount of incentives received was not β = 00002 95 CI −0002 to 0002 p = 0818This trial was funded by the National Institute of Health Research Health Technology Assessment Project No 07/60/43 The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HTA NIHR NHS or the Department of HealthAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee NRES reference number 09/H0710/35 and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards This article does not contain any studies with animals performed by any of the authors
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