Authors: Anne L Stangl Rebecca Bunnell Nafuna Wamai Humphrey Masaba Jonathan Mermin
Publish Date: 2011/12/25
Volume: 21, Issue: 9, Pages: 1655-1663
Abstract
Summary scores derived from the Medical Outcomes Study HIV Health Survey MOSHIV are used to assess treatment impacts among HIVinfected patients in Western settings but have yet to be validated in rural African settings We examined the reliability validity and responsiveness of scores among a prospective cohort of 947 HIV1infected adults initiating antiretroviral therapy between May 2003 and May 2004 in rural UgandaPhysical PHS and mental health MHS summary scores were developed from baseline MOSHIV subdomains using exploratory factor analysis Construct and discriminant validity were established by comparing mean summary scores across known groups of sociodemographic clinical and health status characteristics Effect sizes were calculated to assess responsiveness to therapyReliability of the PHS and MHS scores was 079 and 085 respectively Mean baseline PHS and MHS scores varied significantly by CD4 cell count HIV viral load WHO stage of disease and Karnofsky performance status scores By 12 months on antiretroviral therapy PHS and MHS scores improved by 146 points P 0001 and 139 points P 0001 respectively
Keywords: