Authors: Antonia V Bennett Bryce B Reeve Ethan M Basch Sandra A Mitchell Mathew Meeneghan Claudio L Battaglini Abbie E SmithRyan Brett Phillips Thomas C Shea William A Wood
Publish Date: 2015/11/17
Volume: 25, Issue: 3, Pages: 535-546
Abstract
Adult patients undergoing hematopoietic cell transplant HCT wore pedometers and completed PRO assessments during transplant hospitalization 4 weeks and 4 weeks postdischarge Patient reports of symptomatic treatment toxicities single items from PROCTCAE http//healthcaredeliverycancergov/proctcae and symptoms physical health mental health and quality of life PROMIS® Global10 http//nihpromisorg assessed weekly with 7day recall on Likert scales were compared individually with pedometry data summarized as average daily steps per week using linear mixed modelsThirtytwo patients mean age 55 SD = 14 63 male 84 white 56 autologous 43 allogeneic completed a mean 46 SD = 15 range 1–8 evaluable assessments Regression model coefficients β indicated withinperson decrements in average daily steps were associated with increases in pain β = −852 852 fewer steps per unit increase in pain score p 0001 fatigue β = −886 p 0001 vomiting β = −518 p 001 shaking/chills β = −587 p 001 diarrhea β = −719 p 0001 shortness of breath β = −1018 p 005 reduction in carrying out social activities β = 705 p 001 or physical activities β = 618 p 001 and global physical health β = 101 p 0001 but not global mental health or quality of lifeIn this small sample of HCT recipients more severe symptoms impaired physical health and restrictions in the performance of usual daily activities were associated with statistically significant decrements in objectively measured daily steps Pedometry may be a valuable outcome measure and validation anchor in clinical researchAll procedures performed in studies involving human participants were in accordance with the Ethical Standards of the Institutional and/or National Research Committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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