Journal Title
Title of Journal: Eur Biophys J
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Abbravation: European Biophysics Journal
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Publisher
Springer-Verlag
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Authors: Sophie Laurent Luce Vander Elst Coralie Thirifays Robert N Muller
Publish Date: 2008/04/22
Volume: 37, Issue: 6, Pages: 1007-1014
Abstract
Nuclear magnetic relaxation dispersion NMRD profiles of unilamellar DPPC liposomes incorporating GdDTPAbisamides with alkyl chains of 12 to 18 C atoms in their external and internal layers were recorded in order to study the influence that the chain length and structure of Gdbisamides incorporated in the liposomal membrane have on their proton relaxivity The NMRD profiles recorded at 310 K show that the relaxivity reaches a minimum value when the carbon chain lengths of the phospholipid and of the Gd complex match and is at a maximum in the presence of a carbon–carbon double bond For these DPPC paramagnetic liposomes the longer the aliphatic chains of the complex the larger will be its immobilization in the membrane In addition the presence of an unsaturated carbon–carbon bond in the alkyl chain of the Gd complex induces an increase of its mobility and of its water exchange rate with as a result a much greater efficiency as an MRI contrast agentThe authors thank Mrs Patricia de Francisco for her help in preparing the manuscript This work was supported by the FNRS and the ARC Program 00/05–258 of the French Community of Belgium The support and sponsorship of the COST Actions D18 “Lanthanide Chemistry for Diagnosis and Therapy” and D38 “Metalbased Systems for Molecular Imaging Applications” and of the EMIL NoE of the FP6 of the EC are kindly acknowledged
Keywords:
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- Anticooperativity in diffusion-controlled reactions with pairs of anisotropic domains: a model for the antigen–antibody encounter
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