Authors: Peihua Chen Jinzhi Wu Jie Zhao Ping Wang Jianhong Luo Wei Yang Xiaodong Liu
Publish Date: 2015/06/12
Volume: 44, Issue: 6, Pages: 483-492
Abstract
Polycystic kidney diseaselike PKDL genes that are expressed in sour taste cells have been proposed to be involved in the transduction of sourness by producing offresponses which shows a large inward current after withdrawing the acid stimuli However the underlying mechanisms of offresponses are still unclear Here we demonstrate that an alkali–activated mechanism is responsible for eliciting offresponses as evidenced by both experimental and theoretical analyses In addition we showed that the decaying phase of offset responses in PKD2L1/PKD1L3 channels was substantially accelerated by extracellular Ca2+We thank Dr H Matsunami at Duke University for kindly sharing the constructs of PKD2L1 and PKD1L3 Dr MS Herness at Ohio State University and Dr TA This work is supported by National Basic Research Program of China Grant2013CB910204 to WY Natural Science Foundation of China grant 81171382 and China National Key Basic Research Program grant 2011CB707701 both to XDL National Basic Research Program of China Grant 2014CB910300 and 2010CB912002 both to JHL and Natural Science Foundation of China grant 6130106002 and the National Basic Research Program of China Grant 2015CB352101 both to PW
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