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Title of Journal: Eur Biophys J

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Abbravation: European Biophysics Journal

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Springer-Verlag

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10.1016/0009-2614(89)85239-x

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1432-1017

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Lambda exonuclease digestion of CGG trinucleotide

Authors: R S Conroy A P Koretsky J Moreland
Publish Date: 2009/06/27
Volume: 39, Issue: 2, Pages: 337-
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Abstract

Fragile X syndrome and other trinucleotide diseases are characterized by an elongation of a repeating DNA triplet The ensembleaveraged lambda exonuclease digestion rate of different substrates including one with an elongated FMR1 gene containing 120 CGG repeats was measured using absorption and fluorescence spectroscopy By use of magnetic tweezers sequencedependent digestion rates and pausing was measured for individual lambda exonucleases Within the triplet repeats a lower average and narrower distribution of rates and a higher frequency of pausing was observedRC acknowledge the support of a National Research Council Research Associateship Award and the help of Karen Usdin and Daman Kumari of NIDDK who supplied the elongated FMR1 sequence and helped with preparation replication and isolation of the plasmid and Keir Neuman for critical feedback This research was supported in part by the Intramural Research Program of the NINDS NIH

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