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Title of Journal: Eur Biophys J

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Abbravation: European Biophysics Journal

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Springer-Verlag

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10.1007/bf00887934

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1432-1017

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Blood oxygenation using microbubble suspensions

Authors: Noriaki Matsuki Shingo Ichiba Takuji Ishikawa Osamu Nagano Motohiro Takeda Yoshihito Ujike Takami Yamaguchi
Publish Date: 2012/04/03
Volume: 41, Issue: 6, Pages: 571-578
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Abstract

Microbubbles have been used in a variety of fields and have unique properties for example shrinking collapse long lifetime efficient gas solubility a negatively charged surface and the ability to produce free radicals In medicine microbubbles have been used mainly as diagnostic aids to scan various organs of the body and they have recently been investigated for use in drug and gene delivery However there have been no reports of blood oxygenation by use of oxygen microbubble fluids without shell reagents In this study we demonstrated that nano or microbubbles can achieve oxygen supersaturation of fluids and may be sufficiently small and safe for infusion into blood vessels Although Po2 increases in fluids resulting from use of microbubbles were inhibited by polar solvents normal saline solution NSS was little affected Thus NSS is suitable for production of oxygenrich fluid In addition oxygen microbubble NSS effectively improved hypoxic conditions in blood Thus use of oxygen microbubble nanobubble fluids is a potentially effective novel method for oxygenation of hypoxic tissues for infection control and for anticancer treatment

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